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Stereotactic radiotherapy for lung cancer using a flattening filter free Clinac

The objective of this study was to assess the feasibility of stereotactic radiotherapy for early stage lung cancer using photon beams from a Varian Clinac accelerator operated without a flattening filter. Treatment plans were generated for 10 lung cancer patients with isolated lesions less than 3 cm...

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Autores principales: Vassiliev, Oleg N., Kry, Stephen F., Chang, Joe Y., Balter, Peter A., Titt, Uwe, Mohan, Radhe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5720505/
https://www.ncbi.nlm.nih.gov/pubmed/19223837
http://dx.doi.org/10.1120/jacmp.v10i1.2880
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author Vassiliev, Oleg N.
Kry, Stephen F.
Chang, Joe Y.
Balter, Peter A.
Titt, Uwe
Mohan, Radhe
author_facet Vassiliev, Oleg N.
Kry, Stephen F.
Chang, Joe Y.
Balter, Peter A.
Titt, Uwe
Mohan, Radhe
author_sort Vassiliev, Oleg N.
collection PubMed
description The objective of this study was to assess the feasibility of stereotactic radiotherapy for early stage lung cancer using photon beams from a Varian Clinac accelerator operated without a flattening filter. Treatment plans were generated for 10 lung cancer patients with isolated lesions less than 3 cm in diameter. For each patient, two plans were generated, one with and one without the flattening filter. Plans were generated with Eclipse 8.0 (Varian Medical Systems) commissioned with beam data measured on a Clinac 21EX (Varian Medical Systems) operated with and without the flattening filter. Removal of the flattening filter increased the dose rate. The median beam‐on time per field was reduced from 25 sec (with the filter) to 11 sec (without the filter), increasing the feasibility of breath‐hold treatments and the efficiency of gated treatments. Differences in a dose heterogeneity index for the planning target volume between plans with flattened and unflattened beams were statistically insignificant. Differences in mean doses to organs at risk were small, typically about 10 cGy over the entire treatment. The study concludes that radiotherapy with unflattened beams is feasible and requires substantially less beam‐on time, facilitating breath‐hold and gating techniques. PACS numbers: 87.56.bd, 87.53.Ly
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spelling pubmed-57205052018-04-02 Stereotactic radiotherapy for lung cancer using a flattening filter free Clinac Vassiliev, Oleg N. Kry, Stephen F. Chang, Joe Y. Balter, Peter A. Titt, Uwe Mohan, Radhe J Appl Clin Med Phys Radiation Oncology Physics The objective of this study was to assess the feasibility of stereotactic radiotherapy for early stage lung cancer using photon beams from a Varian Clinac accelerator operated without a flattening filter. Treatment plans were generated for 10 lung cancer patients with isolated lesions less than 3 cm in diameter. For each patient, two plans were generated, one with and one without the flattening filter. Plans were generated with Eclipse 8.0 (Varian Medical Systems) commissioned with beam data measured on a Clinac 21EX (Varian Medical Systems) operated with and without the flattening filter. Removal of the flattening filter increased the dose rate. The median beam‐on time per field was reduced from 25 sec (with the filter) to 11 sec (without the filter), increasing the feasibility of breath‐hold treatments and the efficiency of gated treatments. Differences in a dose heterogeneity index for the planning target volume between plans with flattened and unflattened beams were statistically insignificant. Differences in mean doses to organs at risk were small, typically about 10 cGy over the entire treatment. The study concludes that radiotherapy with unflattened beams is feasible and requires substantially less beam‐on time, facilitating breath‐hold and gating techniques. PACS numbers: 87.56.bd, 87.53.Ly John Wiley and Sons Inc. 2009-01-27 /pmc/articles/PMC5720505/ /pubmed/19223837 http://dx.doi.org/10.1120/jacmp.v10i1.2880 Text en © 2009 The Authors. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/3.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Radiation Oncology Physics
Vassiliev, Oleg N.
Kry, Stephen F.
Chang, Joe Y.
Balter, Peter A.
Titt, Uwe
Mohan, Radhe
Stereotactic radiotherapy for lung cancer using a flattening filter free Clinac
title Stereotactic radiotherapy for lung cancer using a flattening filter free Clinac
title_full Stereotactic radiotherapy for lung cancer using a flattening filter free Clinac
title_fullStr Stereotactic radiotherapy for lung cancer using a flattening filter free Clinac
title_full_unstemmed Stereotactic radiotherapy for lung cancer using a flattening filter free Clinac
title_short Stereotactic radiotherapy for lung cancer using a flattening filter free Clinac
title_sort stereotactic radiotherapy for lung cancer using a flattening filter free clinac
topic Radiation Oncology Physics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5720505/
https://www.ncbi.nlm.nih.gov/pubmed/19223837
http://dx.doi.org/10.1120/jacmp.v10i1.2880
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