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Anticancer Drug-Induced Acute Kidney Injury

Acute kidney injury (AKI) is a growing problem with untoward economic and medical consequences. Anticancer drug toxicity remains an important and increasing cause of AKI. Importantly, drug-induced AKI affects all nephron segments—vasculature, glomerulus, tubules, and interstitium. Recent studies hav...

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Detalles Bibliográficos
Autores principales: Izzedine, Hassan, Perazella, Mark A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5720534/
https://www.ncbi.nlm.nih.gov/pubmed/29318217
http://dx.doi.org/10.1016/j.ekir.2017.02.008
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author Izzedine, Hassan
Perazella, Mark A.
author_facet Izzedine, Hassan
Perazella, Mark A.
author_sort Izzedine, Hassan
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description Acute kidney injury (AKI) is a growing problem with untoward economic and medical consequences. Anticancer drug toxicity remains an important and increasing cause of AKI. Importantly, drug-induced AKI affects all nephron segments—vasculature, glomerulus, tubules, and interstitium. Recent studies have increased insight into the subcellular mechanisms of drug-induced AKI that include direct cellular toxicity and immune-mediated effects. Identification of patients with high-risk cancer before drug exposure may allow prevention or at least a reduction in the development and severity of nephrotoxicity. Recognition of drug-induced AKI and rapid discontinuation (or dose reduction) of the offending agents, when appropriate, are critical to maximizing kidney function recovery. Preventive measures require understanding patient and drug-related risk factors coupled with correcting risk factors, assessing baseline kidney function before initiation of therapy, adjusting the drug dosage and avoiding use of nephrotoxic drug combinations.
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spelling pubmed-57205342018-01-09 Anticancer Drug-Induced Acute Kidney Injury Izzedine, Hassan Perazella, Mark A. Kidney Int Rep Review Acute kidney injury (AKI) is a growing problem with untoward economic and medical consequences. Anticancer drug toxicity remains an important and increasing cause of AKI. Importantly, drug-induced AKI affects all nephron segments—vasculature, glomerulus, tubules, and interstitium. Recent studies have increased insight into the subcellular mechanisms of drug-induced AKI that include direct cellular toxicity and immune-mediated effects. Identification of patients with high-risk cancer before drug exposure may allow prevention or at least a reduction in the development and severity of nephrotoxicity. Recognition of drug-induced AKI and rapid discontinuation (or dose reduction) of the offending agents, when appropriate, are critical to maximizing kidney function recovery. Preventive measures require understanding patient and drug-related risk factors coupled with correcting risk factors, assessing baseline kidney function before initiation of therapy, adjusting the drug dosage and avoiding use of nephrotoxic drug combinations. Elsevier 2017-02-16 /pmc/articles/PMC5720534/ /pubmed/29318217 http://dx.doi.org/10.1016/j.ekir.2017.02.008 Text en © 2017 International Society of Nephrology. Published by Elsevier Inc. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review
Izzedine, Hassan
Perazella, Mark A.
Anticancer Drug-Induced Acute Kidney Injury
title Anticancer Drug-Induced Acute Kidney Injury
title_full Anticancer Drug-Induced Acute Kidney Injury
title_fullStr Anticancer Drug-Induced Acute Kidney Injury
title_full_unstemmed Anticancer Drug-Induced Acute Kidney Injury
title_short Anticancer Drug-Induced Acute Kidney Injury
title_sort anticancer drug-induced acute kidney injury
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5720534/
https://www.ncbi.nlm.nih.gov/pubmed/29318217
http://dx.doi.org/10.1016/j.ekir.2017.02.008
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