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Anticancer Drug-Induced Acute Kidney Injury
Acute kidney injury (AKI) is a growing problem with untoward economic and medical consequences. Anticancer drug toxicity remains an important and increasing cause of AKI. Importantly, drug-induced AKI affects all nephron segments—vasculature, glomerulus, tubules, and interstitium. Recent studies hav...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5720534/ https://www.ncbi.nlm.nih.gov/pubmed/29318217 http://dx.doi.org/10.1016/j.ekir.2017.02.008 |
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author | Izzedine, Hassan Perazella, Mark A. |
author_facet | Izzedine, Hassan Perazella, Mark A. |
author_sort | Izzedine, Hassan |
collection | PubMed |
description | Acute kidney injury (AKI) is a growing problem with untoward economic and medical consequences. Anticancer drug toxicity remains an important and increasing cause of AKI. Importantly, drug-induced AKI affects all nephron segments—vasculature, glomerulus, tubules, and interstitium. Recent studies have increased insight into the subcellular mechanisms of drug-induced AKI that include direct cellular toxicity and immune-mediated effects. Identification of patients with high-risk cancer before drug exposure may allow prevention or at least a reduction in the development and severity of nephrotoxicity. Recognition of drug-induced AKI and rapid discontinuation (or dose reduction) of the offending agents, when appropriate, are critical to maximizing kidney function recovery. Preventive measures require understanding patient and drug-related risk factors coupled with correcting risk factors, assessing baseline kidney function before initiation of therapy, adjusting the drug dosage and avoiding use of nephrotoxic drug combinations. |
format | Online Article Text |
id | pubmed-5720534 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-57205342018-01-09 Anticancer Drug-Induced Acute Kidney Injury Izzedine, Hassan Perazella, Mark A. Kidney Int Rep Review Acute kidney injury (AKI) is a growing problem with untoward economic and medical consequences. Anticancer drug toxicity remains an important and increasing cause of AKI. Importantly, drug-induced AKI affects all nephron segments—vasculature, glomerulus, tubules, and interstitium. Recent studies have increased insight into the subcellular mechanisms of drug-induced AKI that include direct cellular toxicity and immune-mediated effects. Identification of patients with high-risk cancer before drug exposure may allow prevention or at least a reduction in the development and severity of nephrotoxicity. Recognition of drug-induced AKI and rapid discontinuation (or dose reduction) of the offending agents, when appropriate, are critical to maximizing kidney function recovery. Preventive measures require understanding patient and drug-related risk factors coupled with correcting risk factors, assessing baseline kidney function before initiation of therapy, adjusting the drug dosage and avoiding use of nephrotoxic drug combinations. Elsevier 2017-02-16 /pmc/articles/PMC5720534/ /pubmed/29318217 http://dx.doi.org/10.1016/j.ekir.2017.02.008 Text en © 2017 International Society of Nephrology. Published by Elsevier Inc. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Review Izzedine, Hassan Perazella, Mark A. Anticancer Drug-Induced Acute Kidney Injury |
title | Anticancer Drug-Induced Acute Kidney Injury |
title_full | Anticancer Drug-Induced Acute Kidney Injury |
title_fullStr | Anticancer Drug-Induced Acute Kidney Injury |
title_full_unstemmed | Anticancer Drug-Induced Acute Kidney Injury |
title_short | Anticancer Drug-Induced Acute Kidney Injury |
title_sort | anticancer drug-induced acute kidney injury |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5720534/ https://www.ncbi.nlm.nih.gov/pubmed/29318217 http://dx.doi.org/10.1016/j.ekir.2017.02.008 |
work_keys_str_mv | AT izzedinehassan anticancerdruginducedacutekidneyinjury AT perazellamarka anticancerdruginducedacutekidneyinjury |