Bladder-cancer-associated mutations in RXRA activate peroxisome proliferator-activated receptors to drive urothelial proliferation

RXRA regulates transcription as part of a heterodimer with 14 other nuclear receptors, including the peroxisome proliferator-activated receptors (PPARs). Analysis from TCGA raised the possibility that hyperactive PPAR signaling, either due to PPAR gamma gene amplification or RXRA hot-spot mutation (...

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Detalles Bibliográficos
Autores principales: Halstead, Angela M, Kapadia, Chiraag D, Bolzenius, Jennifer, Chu, Clarence E, Schriefer, Andrew, Wartman, Lukas D, Bowman, Gregory R, Arora, Vivek K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5720590/
https://www.ncbi.nlm.nih.gov/pubmed/29143738
http://dx.doi.org/10.7554/eLife.30862

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