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Extending Metformin Use in Diabetic Kidney Disease: A Pharmacokinetic Study in Stage 4 Diabetic Nephropathy

INTRODUCTION: Metformin use in advanced chronic kidney disease is controversial. This study sought to examine the pharmacokinetics, safety, and efficacy of low-dose metformin in patients with type 2 diabetes and stage 4 chronic kidney disease. METHODS: In this open-label, phase I trial, 3 consecutiv...

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Detalles Bibliográficos
Autores principales:	Dissanayake, Ajith Munasinghe, Wheldon, Mark Christopher, Ahmed, Jafar, Hood, Christopher John
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2017
Materias:	Clinical Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5720630/ https://www.ncbi.nlm.nih.gov/pubmed/29318219 http://dx.doi.org/10.1016/j.ekir.2017.03.005

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