Cargando…

Triptolide Promotes Senescence of Prostate Cancer Cells Through Histone Methylation and Heterochromatin Formation

BACKGROUND: Triptolide is a medicinal herb-derived diterpene triepoxide with potent anti-tumor activity, mainly, correlated with its ability to inhibit and inactivate subunits of RNA polymerase II, thereby suppressing global gene transcription. Epigenetic imbalance including histone methylation are...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tamgue, Ousman, Lei, Ming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	West Asia Organization for Cancer Prevention 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5720660/ https://www.ncbi.nlm.nih.gov/pubmed/28952292 http://dx.doi.org/10.22034/APJCP.2017.18.9.2519

Ejemplares similares

Triptolide Modulates the Expression of Inflammation-Associated lncRNA-PACER and lincRNA-p21 in Mycobacterium tuberculosis–Infected Monocyte-Derived Macrophages
por: Tamgue, Ousman, et al.
Publicado: (2021)

The vaccinia virus K7 protein promotes histone methylation associated with heterochromatin formation
por: Teferi, Wondimagegnehu M., et al.
Publicado: (2017)

Triptolide Induces Growth Inhibition and Apoptosis of Human Laryngocarcinoma Cells by Enhancing p53 Activities and Suppressing E6-Mediated p53 Degradation
por: Zhao, Fei, et al.
Publicado: (2013)

Multiple histone modifications in euchromatin promote heterochromatin formation by redundant mechanisms in Saccharomyces cerevisiae
por: Verzijlbergen, Kitty F, et al.
Publicado: (2009)

Methylation of histone H3 at lysine 23 in meiotic heterochromatin
por: Papazvan, Romeo, et al.
Publicado: (2013)

Histone deacetylation promotes transcriptional silencing at facultative heterochromatin
por: Watts, Beth R, et al.
Publicado: (2018)

Senescent mouse cells fail to overtly regulate the HIRA histone chaperone and do not form robust Senescence Associated Heterochromatin Foci
por: Kennedy, Alyssa L, et al.
Publicado: (2010)

Histone H3.3 phosphorylation promotes heterochromatin formation by inhibiting H3K9/K36 histone demethylase
por: Udugama, Maheshi, et al.
Publicado: (2022)

Streptonigrin at low concentration promotes heterochromatin formation
por: Loyola, Andre C., et al.
Publicado: (2020)

HDAC mediated suppression of histone turnover promotes epigenetic stability of heterochromatin
por: Aygün, Ozan, et al.
Publicado: (2013)

PIM-1 modulates cellular senescence and links IL-6 signaling to heterochromatin formation
por: Jin, Bo, et al.
Publicado: (2014)

SIRT3 consolidates heterochromatin and counteracts senescence
por: Diao, Zhiqing, et al.
Publicado: (2021)

Triptolide induces protective autophagy through activation of the CaMKKβ-AMPK signaling pathway in prostate cancer cells
por: Zhao, Fei, et al.
Publicado: (2015)

KMT1 family methyltransferases regulate heterochromatin–nuclear periphery tethering via histone and non‐histone protein methylation
por: Rao, Radhika Arasala, et al.
Publicado: (2019)

The histone chaperone FACT facilitates heterochromatin spreading by regulating histone turnover and H3K9 methylation states
por: Murawska, Magdalena, et al.
Publicado: (2021)

Triptolide inhibits neutrophil extracellular trap formation
por: Guan, Haiyu, et al.
Publicado: (2021)

Stabilizing heterochromatin by DGCR8 alleviates senescence and osteoarthritis
por: Deng, Liping, et al.
Publicado: (2019)

ZKSCAN3 counteracts cellular senescence by stabilizing heterochromatin
por: Hu, Huifang, et al.
Publicado: (2020)

Correction to ‘SIRT3 consolidates heterochromatin and counteracts senescence’
por: Diao, Zhiqing, et al.
Publicado: (2021)

Triptolide Inhibits the AR Signaling Pathway to Suppress the Proliferation of Enzalutamide Resistant Prostate Cancer Cells
por: Han, Yangyang, et al.
Publicado: (2017)

The histone variant H2A.W and linker histone H1 co-regulate heterochromatin accessibility and DNA methylation
por: Bourguet, Pierre, et al.
Publicado: (2021)

Heterochromatin Formation Promotes Longevity and Represses Ribosomal RNA Synthesis
por: Larson, Kimberly, et al.
Publicado: (2012)

Methylation of histone H3K23 blocks DNA damage in pericentric heterochromatin during meiosis
por: Papazyan, Romeo, et al.
Publicado: (2014)

Histone H1 prevents non-CG methylation-mediated small RNA biogenesis in Arabidopsis heterochromatin
por: Choi, Jaemyung, et al.
Publicado: (2021)

Regulated nuclear accumulation of a histone methyltransferase times the onset of heterochromatin formation in C. elegans embryos
por: Mutlu, Beste, et al.
Publicado: (2018)

Ring-Like Distribution of Constitutive Heterochromatin in Bovine Senescent Cells
por: Pichugin, Andrey, et al.
Publicado: (2011)

Nuclear pore density controls heterochromatin reorganization during senescence
por: Boumendil, Charlene, et al.
Publicado: (2019)

Triptolide Inhibits the Proliferation of Prostate Cancer Cells and Down-Regulates SUMO-Specific Protease 1 Expression
por: Huang, Weiwei, et al.
Publicado: (2012)

A role for the histone chaperone DAXX in the structural organization of heterochromatin
por: Rapkin, Lindsy M, et al.
Publicado: (2013)

The histone chaperone DAXX maintains the structural organization of heterochromatin domains
por: Rapkin, Lindsy M., et al.
Publicado: (2015)

Linking replication stress with heterochromatin formation
por: Nikolov, Ivaylo, et al.
Publicado: (2015)

Constitutive heterochromatin formation and transcription in mammals
por: Saksouk, Nehmé, et al.
Publicado: (2015)

H2B ubiquitylation and the histone chaperone Asf1 cooperatively mediate the formation and maintenance of heterochromatin silencing
por: Wu, Meng-Ying, et al.
Publicado: (2017)

Histone H1 Plays a Role in Heterochromatin Formation and VSG Expression Site Silencing in Trypanosoma brucei
por: Povelones, Megan L., et al.
Publicado: (2012)

ATF7IP-Mediated Stabilization of the Histone Methyltransferase SETDB1 Is Essential for Heterochromatin Formation by the HUSH Complex
por: Timms, Richard T., et al.
Publicado: (2016)

The Mi-2 nucleosome remodeler and the Rpd3 histone deacetylase are involved in piRNA-guided heterochromatin formation
por: Mugat, Bruno, et al.
Publicado: (2020)

Deacetylation of H4-K16Ac and heterochromatin assembly in senescence
por: Contrepois, Kévin, et al.
Publicado: (2012)

An embryonic stem cell-specific heterochromatin state promotes core histone exchange in the absence of DNA accessibility
por: Navarro, Carmen, et al.
Publicado: (2020)

Spreading and epigenetic inheritance of heterochromatin require a critical density of histone H3 lysine 9 tri-methylation
por: Cutter DiPiazza, Amber R., et al.
Publicado: (2021)

Pericentric heterochromatin reprogramming by new histone variants during mouse spermiogenesis
por: Govin, Jérôme, et al.
Publicado: (2007)

Cannot write session to /tmp/vufind_sessions/sess_380loajipfe9s9kkggd9vdct3j