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Isoniazid concentrations in hair and plasma area-under-the-curve exposure among children with tuberculosis

We measured hair and plasma concentrations of isoniazid among sixteen children with tuberculosis who underwent personal or video-assisted directly observed therapy and thus had 100% adherence. This study therefore defined typical isoniazid exposure parameters after two months of treatment among full...

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Autores principales: Mave, Vidya, Kinikar, Aarti, Kagal, Anju, Nimkar, Smita, Koli, Hari, Khwaja, Sultanat, Bharadwaj, Renu, Gerona, Roy, Wen, Anita, Ramachandran, Geetha, Kumar, Hemanth, Bacchetti, Peter, Dooley, Kelly E., Gupte, Nikhil, Gupta, Amita, Gandhi, Monica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5720757/
https://www.ncbi.nlm.nih.gov/pubmed/29216273
http://dx.doi.org/10.1371/journal.pone.0189101
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author Mave, Vidya
Kinikar, Aarti
Kagal, Anju
Nimkar, Smita
Koli, Hari
Khwaja, Sultanat
Bharadwaj, Renu
Gerona, Roy
Wen, Anita
Ramachandran, Geetha
Kumar, Hemanth
Bacchetti, Peter
Dooley, Kelly E.
Gupte, Nikhil
Gupta, Amita
Gandhi, Monica
author_facet Mave, Vidya
Kinikar, Aarti
Kagal, Anju
Nimkar, Smita
Koli, Hari
Khwaja, Sultanat
Bharadwaj, Renu
Gerona, Roy
Wen, Anita
Ramachandran, Geetha
Kumar, Hemanth
Bacchetti, Peter
Dooley, Kelly E.
Gupte, Nikhil
Gupta, Amita
Gandhi, Monica
author_sort Mave, Vidya
collection PubMed
description We measured hair and plasma concentrations of isoniazid among sixteen children with tuberculosis who underwent personal or video-assisted directly observed therapy and thus had 100% adherence. This study therefore defined typical isoniazid exposure parameters after two months of treatment among fully-adherent patients in both hair and plasma (plasma area under the concentration-time curve, AUC, estimated using pharmacokinetic data collected 0, 2, 4, and 6 hours after drug administration). We found that INH levels in hair among highly-adherent individuals did not correlate well with plasma AUC or trough concentrations, suggesting that each measure may provide incremental and complementary information regarding drug exposure in the context of TB treatment.
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spelling pubmed-57207572017-12-15 Isoniazid concentrations in hair and plasma area-under-the-curve exposure among children with tuberculosis Mave, Vidya Kinikar, Aarti Kagal, Anju Nimkar, Smita Koli, Hari Khwaja, Sultanat Bharadwaj, Renu Gerona, Roy Wen, Anita Ramachandran, Geetha Kumar, Hemanth Bacchetti, Peter Dooley, Kelly E. Gupte, Nikhil Gupta, Amita Gandhi, Monica PLoS One Research Article We measured hair and plasma concentrations of isoniazid among sixteen children with tuberculosis who underwent personal or video-assisted directly observed therapy and thus had 100% adherence. This study therefore defined typical isoniazid exposure parameters after two months of treatment among fully-adherent patients in both hair and plasma (plasma area under the concentration-time curve, AUC, estimated using pharmacokinetic data collected 0, 2, 4, and 6 hours after drug administration). We found that INH levels in hair among highly-adherent individuals did not correlate well with plasma AUC or trough concentrations, suggesting that each measure may provide incremental and complementary information regarding drug exposure in the context of TB treatment. Public Library of Science 2017-12-07 /pmc/articles/PMC5720757/ /pubmed/29216273 http://dx.doi.org/10.1371/journal.pone.0189101 Text en © 2017 Mave et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Mave, Vidya
Kinikar, Aarti
Kagal, Anju
Nimkar, Smita
Koli, Hari
Khwaja, Sultanat
Bharadwaj, Renu
Gerona, Roy
Wen, Anita
Ramachandran, Geetha
Kumar, Hemanth
Bacchetti, Peter
Dooley, Kelly E.
Gupte, Nikhil
Gupta, Amita
Gandhi, Monica
Isoniazid concentrations in hair and plasma area-under-the-curve exposure among children with tuberculosis
title Isoniazid concentrations in hair and plasma area-under-the-curve exposure among children with tuberculosis
title_full Isoniazid concentrations in hair and plasma area-under-the-curve exposure among children with tuberculosis
title_fullStr Isoniazid concentrations in hair and plasma area-under-the-curve exposure among children with tuberculosis
title_full_unstemmed Isoniazid concentrations in hair and plasma area-under-the-curve exposure among children with tuberculosis
title_short Isoniazid concentrations in hair and plasma area-under-the-curve exposure among children with tuberculosis
title_sort isoniazid concentrations in hair and plasma area-under-the-curve exposure among children with tuberculosis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5720757/
https://www.ncbi.nlm.nih.gov/pubmed/29216273
http://dx.doi.org/10.1371/journal.pone.0189101
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