Shift toward greater pathologic post-myocardial infarction remodeling with loss of the adaptive hypertrophic signaling of alpha1 adrenergic receptors in mice

RATIONALE: We have hypothesized that post-infarction cardiac remodeling can be influenced by shifts in the balance between intracellular mediators of “pathologic” and “physiologic” hypertrophy. Although alpha1 adrenergic receptors (alpha1-ARs) mediate pro-adaptive hypertrophy during pressure overloa...

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Detalles Bibliográficos
Autores principales: Yeh, Che-Chung, Fan, Yanying, Xu, Yanchun, Yang, Yi-Lin, Simpson, Paul C., Mann, Michael J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5720786/
https://www.ncbi.nlm.nih.gov/pubmed/29216197
http://dx.doi.org/10.1371/journal.pone.0188471

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