Cargando…

Pre-clinical antigenicity studies of an innovative multivalent vaccine for human visceral leishmaniasis

The notion that previous infection by Leishmania spp. in endemic areas leads to robust anti-Leishmania immunity, supports vaccination as a potentially effective approach to prevent disease development. Nevertheless, to date there is no vaccine available for human leishmaniasis. We optimized and asse...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cecílio, Pedro, Pérez-Cabezas, Begoña, Fernández, Laura, Moreno, Javier, Carrillo, Eugenia, Requena, José M., Fichera, Epifanio, Reed, Steven G., Coler, Rhea N., Kamhawi, Shaden, Oliveira, Fabiano, Valenzuela, Jesus G., Gradoni, Luigi, Glueck, Reinhard, Gupta, Gaurav, Cordeiro-da-Silva, Anabela
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5720812/ https://www.ncbi.nlm.nih.gov/pubmed/29176865 http://dx.doi.org/10.1371/journal.pntd.0005951

Ejemplares similares

Protective Efficacy in a Hamster Model of a Multivalent Vaccine for Human Visceral Leishmaniasis (MuLeVaClin) Consisting of the KMP11, LEISH-F3+, and LJL143 Antigens in Virosomes, Plus GLA-SE Adjuvant
por: Fernández, Laura, et al.
Publicado: (2021)

Vector Saliva in Vaccines for Visceral Leishmaniasis: A Brief Encounter of High Consequence?
por: Kamhawi, Shaden, et al.
Publicado: (2014)

Understanding Resistance vs. Susceptibility in Visceral Leishmaniasis Using Mouse Models of Leishmania infantum Infection
por: Pérez-Cabezas, Begoña, et al.
Publicado: (2019)

Biomarkers for Zoonotic Visceral Leishmaniasis in Latin America
por: Brodskyn, Claudia I., et al.
Publicado: (2018)

A defined subunit vaccine that protects against vector-borne visceral leishmaniasis
por: Duthie, Malcolm S., et al.
Publicado: (2017)

Comparative salivary gland transcriptomics of sandfly vectors of visceral leishmaniasis
por: Anderson, Jennifer M, et al.
Publicado: (2006)

Visceral Leishmaniasis Treatment, Italy
por: Gradoni, Luigi, et al.
Publicado: (2003)

Sand flies: Basic information on the vectors of leishmaniasis and their interactions with Leishmania parasites
por: Cecílio, Pedro, et al.
Publicado: (2022)

The yin and yang of leishmaniasis control
por: Kamhawi, Shaden
Publicado: (2017)

Centrin-deficient Leishmania mexicana confers protection against Old World visceral leishmaniasis
por: Karmakar, Subir, et al.
Publicado: (2022)

Building Research and Development Capacity for Neglected Tropical Diseases Impacting Leishmaniasis in the Middle East and North Africa: A Case Study
por: Rafati, Sima, et al.
Publicado: (2015)

Strategic evaluation of vaccine candidate antigens for the prevention of Visceral Leishmaniasis
por: Duthie, Malcolm S., et al.
Publicado: (2016)

Sand Fly Salivary Proteins Induce Strong Cellular Immunity in a Natural Reservoir of Visceral Leishmaniasis with Adverse Consequences for Leishmania
por: Collin, Nicolas, et al.
Publicado: (2009)

Coinfection With Trypanosoma brucei Confers Protection Against Cutaneous Leishmaniasis
por: Pereira, Lais, et al.
Publicado: (2018)

Immunity to Visceral Leishmaniasis
por: Ali, Nahid, et al.
Publicado: (2012)

Implicating bites from a leishmaniasis sand fly vector in the loss of tolerance in pemphigus
por: Marzouki, Soumaya, et al.
Publicado: (2020)

Circulating Biomarkers of Immune Activation, Oxidative Stress and Inflammation Characterize Severe Canine Visceral Leishmaniasis
por: Solcà, Manuela S., et al.
Publicado: (2016)

Immunity to Distinct Sand Fly Salivary Proteins Primes the Anti-Leishmania Immune Response towards Protection or Exacerbation of Disease
por: Oliveira, Fabiano, et al.
Publicado: (2008)

Canine visceral leishmaniasis: Diagnosis and management of the reservoir living among us
por: Travi, Bruno L., et al.
Publicado: (2018)

Interleukin-27 Early Impacts Leishmania infantum Infection in Mice and Correlates with Active Visceral Disease in Humans
por: Pérez-Cabezas, Begoña, et al.
Publicado: (2016)

Evaluation of diagnostic performance of rK28 ELISA using urine for diagnosis of visceral leishmaniasis
por: Ghosh, Prakash, et al.
Publicado: (2016)

Epidemiologic Aspects of an Emerging Focus of Visceral Leishmaniasis in Tbilisi, Georgia
por: Giorgobiani, Ekaterina, et al.
Publicado: (2011)

Therapeutic Options for Visceral Leishmaniasis
por: Monge-Maillo, Begoña, et al.
Publicado: (2013)

Preclinical validation of a live attenuated dermotropic Leishmania vaccine against vector transmitted fatal visceral leishmaniasis
por: Karmakar, Subir, et al.
Publicado: (2021)

New Insights Into the Transmissibility of Leishmania infantum From Dogs to Sand Flies: Experimental Vector-Transmission Reveals Persistent Parasite Depots at Bite Sites
por: Aslan, Hamide, et al.
Publicado: (2016)

Immune response dynamics and Lutzomyia longipalpis exposure characterize a biosignature of visceral leishmaniasis susceptibility in a canine cohort
por: Solcà, Manuela da Silva, et al.
Publicado: (2021)

Pediatric Visceral Leishmaniasis in Albania: A Retrospective Analysis of 1,210 Consecutive Hospitalized Patients (1995–2009)
por: Petrela, Raida, et al.
Publicado: (2010)

The human immune response to saliva of Phlebotomus alexandri, the vector of visceral leishmaniasis in Iraq, and its relationship to sand fly exposure and infection
por: Lakhal-Naouar, Ines, et al.
Publicado: (2021)

Deception and Manipulation: The Arms of Leishmania, a Successful Parasite
por: Cecílio, Pedro, et al.
Publicado: (2014)

Visceral leishmaniasis
por: Sundar, Shyam
Publicado: (2015)

Prevalence of Cutaneous Leishmaniasis in Districts of High and Low Endemicity in Mali
por: Traoré, Bourama, et al.
Publicado: (2016)

Visceral Dissemination of Mucocutaneous Leishmaniasis in a Kidney Transplant Recipient
por: Marques, Nídia, et al.
Publicado: (2020)

Correction: Prevalence of Cutaneous Leishmaniasis in Districts of High and Low Endemicity in Mali
por: Traoré, Bourama, et al.
Publicado: (2017)

Visceral Leishmaniasis and HIV Coinfection in the Mediterranean Region
por: Monge-Maillo, Begoña, et al.
Publicado: (2014)

Engineering a vector-based pan-Leishmania vaccine for humans: proof of principle
por: Cecílio, Pedro, et al.
Publicado: (2020)

Sequential blood meals augment vector infectiousness by promoting Leishmania replication and triggering amplification of metacyclics via a novel retroleptomonad developmental stage
por: Serafim, Tiago D., et al.
Publicado: (2018)

Leishmania infection induces a limited differential gene expression in the sand fly midgut
por: Coutinho-Abreu, Iliano V., et al.
Publicado: (2020)

Distinct gene expression patterns in vector-residing Leishmania infantum identify parasite stage-enriched markers
por: Coutinho-Abreu, Iliano V., et al.
Publicado: (2020)

The Leishmania infantum PUF proteins are targets of the humoral response during visceral leishmaniasis
por: Folgueira, Cristina, et al.
Publicado: (2010)

Development of a Natural Model of Cutaneous Leishmaniasis: Powerful Effects of Vector Saliva and Saliva Preexposure on the Long-Term Outcome of Leishmania major Infection in the Mouse Ear Dermis
por: Belkaid, Yasmine, et al.
Publicado: (1998)

Cannot write session to /tmp/vufind_sessions/sess_hb8je7iosonqeq8s3edbi393l2