Inhibition of group-I metabotropic glutamate receptors protects against prion toxicity

Prion infections cause inexorable, progressive neurological dysfunction and neurodegeneration. Expression of the cellular prion protein PrP(C) is required for toxicity, suggesting the existence of deleterious PrP(C)-dependent signaling cascades. Because group-I metabotropic glutamate receptors (mGlu...

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Detalles Bibliográficos
Autores principales: Goniotaki, Despoina, Lakkaraju, Asvin K. K., Shrivastava, Amulya N., Bakirci, Pamela, Sorce, Silvia, Senatore, Assunta, Marpakwar, Rajlakshmi, Hornemann, Simone, Gasparini, Fabrizio, Triller, Antoine, Aguzzi, Adriano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5720820/
https://www.ncbi.nlm.nih.gov/pubmed/29176838
http://dx.doi.org/10.1371/journal.ppat.1006733

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