Asprosin is a centrally-acting orexigenic hormone

Asprosin is a recently discovered fasting-induced hormone that promotes hepatic glucose production. Here, we demonstrate that plasma asprosin crosses the blood-brain-barrier and directly activates orexigenic AgRP(+) neurons via a cAMP-dependent pathway. This signaling results in inhibition of downst...

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Detalles Bibliográficos
Autores principales: Duerrschmid, Clemens, He, Yanlin, Wang, Chunmei, Li, Chia, Bournat, Juan C., Romere, Chase, Saha, Pradip K., Lee, Mark E., Phillips, Kevin J., Jain, Mahim, Jia, Peilin, Zhao, Zhongming, Farias, Monica, Wu, Qi, Milewicz, Dianna M., Sutton, V. Reid, Moore, David D., Butte, Nancy F., Krashes, Michael J., Xu, Yong, Chopra, Atul R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5720914/
https://www.ncbi.nlm.nih.gov/pubmed/29106398
http://dx.doi.org/10.1038/nm.4432

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