Persistent diarrhoea in a 5-month-old baby carrying Vibrio cholerae nonO1/nonO139 producing Haitian cholera toxin

Cholera toxin (CT) is the principal virulence factor of Vibrio cholerae for fatal cholera diarrhoea. Serogroups O1 and O139 harbour CT and are known to be epidemic strains. The remaining serogroups (nonO1/nonO139) are non-toxigenic and may be associated with mild disease. O1 serogroup emerged with a...

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Detalles Bibliográficos
Autores principales: Kumar, P., Karmakar, S., Prasad, R., Chopra, R., Khandelwal, S., Gupta, S., Dhariwal, A.C., Yadav, P., Yadava, P.K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
New Microbes in Human
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5721208/
https://www.ncbi.nlm.nih.gov/pubmed/29234496
http://dx.doi.org/10.1016/j.nmni.2017.10.008
Descripción
Sumario:Cholera toxin (CT) is the principal virulence factor of Vibrio cholerae for fatal cholera diarrhoea. Serogroups O1 and O139 harbour CT and are known to be epidemic strains. The remaining serogroups (nonO1/nonO139) are non-toxigenic and may be associated with mild disease. O1 serogroup emerged with a variant of CT known as Haitian cholera toxin (HCT). The HCT strains are hypervirulent and have been associated with severe cholera outbreaks in India, Western Africa and Haiti. Here, we report the presence of HCT (ctxB7) in a nonO1/nonO139 isolate causing persistent diarrhoea.

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