Persistent diarrhoea in a 5-month-old baby carrying Vibrio cholerae nonO1/nonO139 producing Haitian cholera toxin

Cholera toxin (CT) is the principal virulence factor of Vibrio cholerae for fatal cholera diarrhoea. Serogroups O1 and O139 harbour CT and are known to be epidemic strains. The remaining serogroups (nonO1/nonO139) are non-toxigenic and may be associated with mild disease. O1 serogroup emerged with a...

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Autores principales: Kumar, P., Karmakar, S., Prasad, R., Chopra, R., Khandelwal, S., Gupta, S., Dhariwal, A.C., Yadav, P., Yadava, P.K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
New Microbes in Human
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5721208/
https://www.ncbi.nlm.nih.gov/pubmed/29234496
http://dx.doi.org/10.1016/j.nmni.2017.10.008
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author Kumar, P.
Karmakar, S.
Prasad, R.
Chopra, R.
Khandelwal, S.
Gupta, S.
Dhariwal, A.C.
Yadav, P.
Yadava, P.K.
author_facet Kumar, P.
Karmakar, S.
Prasad, R.
Chopra, R.
Khandelwal, S.
Gupta, S.
Dhariwal, A.C.
Yadav, P.
Yadava, P.K.
author_sort Kumar, P.
collection PubMed
description Cholera toxin (CT) is the principal virulence factor of Vibrio cholerae for fatal cholera diarrhoea. Serogroups O1 and O139 harbour CT and are known to be epidemic strains. The remaining serogroups (nonO1/nonO139) are non-toxigenic and may be associated with mild disease. O1 serogroup emerged with a variant of CT known as Haitian cholera toxin (HCT). The HCT strains are hypervirulent and have been associated with severe cholera outbreaks in India, Western Africa and Haiti. Here, we report the presence of HCT (ctxB7) in a nonO1/nonO139 isolate causing persistent diarrhoea.
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spelling pubmed-57212082017-12-11 Persistent diarrhoea in a 5-month-old baby carrying Vibrio cholerae nonO1/nonO139 producing Haitian cholera toxin Kumar, P. Karmakar, S. Prasad, R. Chopra, R. Khandelwal, S. Gupta, S. Dhariwal, A.C. Yadav, P. Yadava, P.K. New Microbes New Infect New Microbes in Human Cholera toxin (CT) is the principal virulence factor of Vibrio cholerae for fatal cholera diarrhoea. Serogroups O1 and O139 harbour CT and are known to be epidemic strains. The remaining serogroups (nonO1/nonO139) are non-toxigenic and may be associated with mild disease. O1 serogroup emerged with a variant of CT known as Haitian cholera toxin (HCT). The HCT strains are hypervirulent and have been associated with severe cholera outbreaks in India, Western Africa and Haiti. Here, we report the presence of HCT (ctxB7) in a nonO1/nonO139 isolate causing persistent diarrhoea. Elsevier 2017-11-28 /pmc/articles/PMC5721208/ /pubmed/29234496 http://dx.doi.org/10.1016/j.nmni.2017.10.008 Text en © 2017 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle New Microbes in Human
Kumar, P.
Karmakar, S.
Prasad, R.
Chopra, R.
Khandelwal, S.
Gupta, S.
Dhariwal, A.C.
Yadav, P.
Yadava, P.K.
Persistent diarrhoea in a 5-month-old baby carrying Vibrio cholerae nonO1/nonO139 producing Haitian cholera toxin
title Persistent diarrhoea in a 5-month-old baby carrying Vibrio cholerae nonO1/nonO139 producing Haitian cholera toxin
title_full Persistent diarrhoea in a 5-month-old baby carrying Vibrio cholerae nonO1/nonO139 producing Haitian cholera toxin
title_fullStr Persistent diarrhoea in a 5-month-old baby carrying Vibrio cholerae nonO1/nonO139 producing Haitian cholera toxin
title_full_unstemmed Persistent diarrhoea in a 5-month-old baby carrying Vibrio cholerae nonO1/nonO139 producing Haitian cholera toxin
title_short Persistent diarrhoea in a 5-month-old baby carrying Vibrio cholerae nonO1/nonO139 producing Haitian cholera toxin
title_sort persistent diarrhoea in a 5-month-old baby carrying vibrio cholerae nono1/nono139 producing haitian cholera toxin
topic New Microbes in Human
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5721208/
https://www.ncbi.nlm.nih.gov/pubmed/29234496
http://dx.doi.org/10.1016/j.nmni.2017.10.008
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