MicroRNA therapy inhibits hepatoblastoma growth in vivo by targeting β‐catenin and Wnt signaling

Hepatoblastoma (HBL) is the most common pediatric liver cancer. In this malignant neoplasm, beta‐catenin protein accumulates and increases Wnt signaling due to recurrent activating mutations in the catenin‐beta 1 (CTNNB1) gene. Therefore, beta‐catenin is a key therapeutic target in HBL. However, con...

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Detalles Bibliográficos
Autores principales: Indersie, Emilie, Lesjean, Sarah, Hooks, Katarzyna B., Sagliocco, Francis, Ernault, Tony, Cairo, Stefano, Merched‐Sauvage, Maria, Rullier, Anne, Le Bail, Brigitte, Taque, Sophie, Grotzer, Michael, Branchereau, Sophie, Guettier, Catherine, Fabre, Monique, Brugières, Laurence, Hagedorn, Martin, Buendia, Marie‐Annick, Grosset, Christophe F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5721429/
https://www.ncbi.nlm.nih.gov/pubmed/29404451
http://dx.doi.org/10.1002/hep4.1029

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