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Up‐regulation of golgi α‐mannosidase IA and down‐regulation of golgi α‐mannosidase IC activates unfolded protein response during hepatocarcinogenesis
α‐1,2 mannosidases, key enzymes in N‐glycosylation, are required for the formation of mature glycoproteins in eukaryotes. Aberrant regulation of α‐1,2 mannosidases can result in cancer, although the underlying mechanisms are unclear. Here, we report the distinct roles of α‐1,2 mannosidase subtypes (...
Autores principales: | Tu, Hsiao‐Chen, Hsiao, Yung‐Chun, Yang, Wan‐Yu, Tsai, Shin‐Lin, Lin, Hua‐Kuo, Liao, Chong‐Yi, Lu, Jeng‐Wei, Chou, Yu‐Ting, Wang, Horng‐Dar, Yuh, Chiou‐Hwa |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5721452/ https://www.ncbi.nlm.nih.gov/pubmed/29404456 http://dx.doi.org/10.1002/hep4.1032 |
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