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Treatment with a DNA methyltransferase inhibitor feminizes zebrafish and induces long-term expression changes in the gonads
BACKGROUND: The role of epigenetic modifications such as DNA methylation during vertebrate sexual development is far from being clear. Using the zebrafish model, we tested the effects of one of the most common DNA methyltransferase (dnmt) inhibitor, 5-aza-2′-deoxycytidine (5-aza-dC), which is approv...
Autores principales: | Ribas, Laia, Vanezis, Konstantinos, Imués, Marco Antonio, Piferrer, Francesc |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5721477/ https://www.ncbi.nlm.nih.gov/pubmed/29216900 http://dx.doi.org/10.1186/s13072-017-0168-7 |
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