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A case of large cell neuroendocrine carcinoma of the uterine cervix misdiagnosed as adenocarcinoma in Thinprep cytology test

Large cell neuroendocrine carcinoma (LCNEC) of uterine cervix is a rare malignancy with aggressive behavior and poor clinical outcome even in its early stage. Few cytopathologic features of cervical LCNEC have been reported previously. A 57-year-old postmenopausal African American female, presented...

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Autores principales: Nam, Jong-Hee, Na, Jongin, Kim, Nah-Ihm, Kim, Ga-Eon, Park, Chang-Soo, Choi, Yoo-Duk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5721486/
https://www.ncbi.nlm.nih.gov/pubmed/29259654
http://dx.doi.org/10.4103/cytojournal.cytojournal_17_17
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author Nam, Jong-Hee
Na, Jongin
Kim, Nah-Ihm
Kim, Ga-Eon
Park, Chang-Soo
Choi, Yoo-Duk
author_facet Nam, Jong-Hee
Na, Jongin
Kim, Nah-Ihm
Kim, Ga-Eon
Park, Chang-Soo
Choi, Yoo-Duk
author_sort Nam, Jong-Hee
collection PubMed
description Large cell neuroendocrine carcinoma (LCNEC) of uterine cervix is a rare malignancy with aggressive behavior and poor clinical outcome even in its early stage. Few cytopathologic features of cervical LCNEC have been reported previously. A 57-year-old postmenopausal African American female, presented to the local health department with a chief complaint of heavy vaginal bleeding. A 45-year-old female presented with 20 months of vaginal pruritus and foul odor. Cervical malignancy was suspected by pelvis magnetic resonance imaging. Thinprep cytology test demonstrated ball-like tumor cell clusters in a necrotic background. Cytologic diagnosis of adenocarcinoma was rendered. However, the histologic and immunohistochemical examination of cervical biopsy revealed the LCNEC of the uterine cervix. Due to its rarity, LCNEC may pose a diagnostic challenge in cervical cytology. Cytopathologists should pay attention to the cytological features of cervical LCNEC, such as rosettoid pattern, nuclear molding, and thin nuclear membrane for differentiation from other mimics.
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spelling pubmed-57214862017-12-19 A case of large cell neuroendocrine carcinoma of the uterine cervix misdiagnosed as adenocarcinoma in Thinprep cytology test Nam, Jong-Hee Na, Jongin Kim, Nah-Ihm Kim, Ga-Eon Park, Chang-Soo Choi, Yoo-Duk Cytojournal Case Report Large cell neuroendocrine carcinoma (LCNEC) of uterine cervix is a rare malignancy with aggressive behavior and poor clinical outcome even in its early stage. Few cytopathologic features of cervical LCNEC have been reported previously. A 57-year-old postmenopausal African American female, presented to the local health department with a chief complaint of heavy vaginal bleeding. A 45-year-old female presented with 20 months of vaginal pruritus and foul odor. Cervical malignancy was suspected by pelvis magnetic resonance imaging. Thinprep cytology test demonstrated ball-like tumor cell clusters in a necrotic background. Cytologic diagnosis of adenocarcinoma was rendered. However, the histologic and immunohistochemical examination of cervical biopsy revealed the LCNEC of the uterine cervix. Due to its rarity, LCNEC may pose a diagnostic challenge in cervical cytology. Cytopathologists should pay attention to the cytological features of cervical LCNEC, such as rosettoid pattern, nuclear molding, and thin nuclear membrane for differentiation from other mimics. Medknow Publications & Media Pvt Ltd 2017-11-24 /pmc/articles/PMC5721486/ /pubmed/29259654 http://dx.doi.org/10.4103/cytojournal.cytojournal_17_17 Text en Copyright: © 2017 Nam, et al.; Licensee Cytopathology Foundation Inc. http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Case Report
Nam, Jong-Hee
Na, Jongin
Kim, Nah-Ihm
Kim, Ga-Eon
Park, Chang-Soo
Choi, Yoo-Duk
A case of large cell neuroendocrine carcinoma of the uterine cervix misdiagnosed as adenocarcinoma in Thinprep cytology test
title A case of large cell neuroendocrine carcinoma of the uterine cervix misdiagnosed as adenocarcinoma in Thinprep cytology test
title_full A case of large cell neuroendocrine carcinoma of the uterine cervix misdiagnosed as adenocarcinoma in Thinprep cytology test
title_fullStr A case of large cell neuroendocrine carcinoma of the uterine cervix misdiagnosed as adenocarcinoma in Thinprep cytology test
title_full_unstemmed A case of large cell neuroendocrine carcinoma of the uterine cervix misdiagnosed as adenocarcinoma in Thinprep cytology test
title_short A case of large cell neuroendocrine carcinoma of the uterine cervix misdiagnosed as adenocarcinoma in Thinprep cytology test
title_sort case of large cell neuroendocrine carcinoma of the uterine cervix misdiagnosed as adenocarcinoma in thinprep cytology test
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5721486/
https://www.ncbi.nlm.nih.gov/pubmed/29259654
http://dx.doi.org/10.4103/cytojournal.cytojournal_17_17
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