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Association between exercise habits and subcortical gray matter volumes in healthy elderly people: A population-based study in Japan

BACKGROUND AND AIMS: The relationship between exercise and subcortical gray matter volume is not well understood in the elderly population, although reports indicate that exercise may prevent cortical gray matter atrophy. To elucidate this association in the elderly, we measured subcortical gray mat...

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Autores principales: Yamamoto, Mikie, Wada-Isoe, Kenji, Yamashita, Fumio, Nakashita, Satoko, Kishi, Masafumi, Tanaka, Kenichiro, Yamawaki, Mika, Nakashima, Kenji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5721551/
https://www.ncbi.nlm.nih.gov/pubmed/29260016
http://dx.doi.org/10.1016/j.ensci.2017.03.002
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author Yamamoto, Mikie
Wada-Isoe, Kenji
Yamashita, Fumio
Nakashita, Satoko
Kishi, Masafumi
Tanaka, Kenichiro
Yamawaki, Mika
Nakashima, Kenji
author_facet Yamamoto, Mikie
Wada-Isoe, Kenji
Yamashita, Fumio
Nakashita, Satoko
Kishi, Masafumi
Tanaka, Kenichiro
Yamawaki, Mika
Nakashima, Kenji
author_sort Yamamoto, Mikie
collection PubMed
description BACKGROUND AND AIMS: The relationship between exercise and subcortical gray matter volume is not well understood in the elderly population, although reports indicate that exercise may prevent cortical gray matter atrophy. To elucidate this association in the elderly, we measured subcortical gray matter volume and correlated this with volumes to exercise habits in a community-based cohort study in Japan. METHODS: Subjects without mild cognitive impairment or dementia (n = 280, 35% male, mean age 73.1 ± 5.9 years) were evaluated using the Mini-Mental State Examination (MMSE), an exercise habit questionnaire, and brain magnetic resonance imaging. Subcortical gray matter volume was compared between groups based on the presence/absence of exercise habits. The MMSE was re-administered 3 years after the baseline examination. RESULTS: Ninety-one subjects (32.5%) reported exercise habits (exercise group), and 189 subjects (67.5%) reported no exercise habits (non-exercise group). Volumetric analysis revealed that the volumes in the exercise group were greater in the left hippocampus (p = 0.042) and bilateral nucleus accumbens (left, p = 0.047; right, p = 0.007) compared to those of the non-exercise group. Among the 195 subjects who received a follow-up MMSE examination, the normalized intra-cranial volumes of the left nucleus accumbens (p = 0.004) and right amygdala (p = 0.014)showed significant association with a decline in the follow-up MMSE score. CONCLUSION: Subjects with exercise habits show larger subcortical gray matter volumes than subjects without exercise habits in community-dwelling elderly subjects in Japan. Specifically, the volume of the nucleus accumbens correlates with both exercise habits and cognitive preservation.
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spelling pubmed-57215512017-12-19 Association between exercise habits and subcortical gray matter volumes in healthy elderly people: A population-based study in Japan Yamamoto, Mikie Wada-Isoe, Kenji Yamashita, Fumio Nakashita, Satoko Kishi, Masafumi Tanaka, Kenichiro Yamawaki, Mika Nakashima, Kenji eNeurologicalSci Original Article BACKGROUND AND AIMS: The relationship between exercise and subcortical gray matter volume is not well understood in the elderly population, although reports indicate that exercise may prevent cortical gray matter atrophy. To elucidate this association in the elderly, we measured subcortical gray matter volume and correlated this with volumes to exercise habits in a community-based cohort study in Japan. METHODS: Subjects without mild cognitive impairment or dementia (n = 280, 35% male, mean age 73.1 ± 5.9 years) were evaluated using the Mini-Mental State Examination (MMSE), an exercise habit questionnaire, and brain magnetic resonance imaging. Subcortical gray matter volume was compared between groups based on the presence/absence of exercise habits. The MMSE was re-administered 3 years after the baseline examination. RESULTS: Ninety-one subjects (32.5%) reported exercise habits (exercise group), and 189 subjects (67.5%) reported no exercise habits (non-exercise group). Volumetric analysis revealed that the volumes in the exercise group were greater in the left hippocampus (p = 0.042) and bilateral nucleus accumbens (left, p = 0.047; right, p = 0.007) compared to those of the non-exercise group. Among the 195 subjects who received a follow-up MMSE examination, the normalized intra-cranial volumes of the left nucleus accumbens (p = 0.004) and right amygdala (p = 0.014)showed significant association with a decline in the follow-up MMSE score. CONCLUSION: Subjects with exercise habits show larger subcortical gray matter volumes than subjects without exercise habits in community-dwelling elderly subjects in Japan. Specifically, the volume of the nucleus accumbens correlates with both exercise habits and cognitive preservation. Elsevier 2017-03-06 /pmc/articles/PMC5721551/ /pubmed/29260016 http://dx.doi.org/10.1016/j.ensci.2017.03.002 Text en © 2017 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Article
Yamamoto, Mikie
Wada-Isoe, Kenji
Yamashita, Fumio
Nakashita, Satoko
Kishi, Masafumi
Tanaka, Kenichiro
Yamawaki, Mika
Nakashima, Kenji
Association between exercise habits and subcortical gray matter volumes in healthy elderly people: A population-based study in Japan
title Association between exercise habits and subcortical gray matter volumes in healthy elderly people: A population-based study in Japan
title_full Association between exercise habits and subcortical gray matter volumes in healthy elderly people: A population-based study in Japan
title_fullStr Association between exercise habits and subcortical gray matter volumes in healthy elderly people: A population-based study in Japan
title_full_unstemmed Association between exercise habits and subcortical gray matter volumes in healthy elderly people: A population-based study in Japan
title_short Association between exercise habits and subcortical gray matter volumes in healthy elderly people: A population-based study in Japan
title_sort association between exercise habits and subcortical gray matter volumes in healthy elderly people: a population-based study in japan
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5721551/
https://www.ncbi.nlm.nih.gov/pubmed/29260016
http://dx.doi.org/10.1016/j.ensci.2017.03.002
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