High PR3-ANCA positivity in a patient with chronic inflammatory demyelinating polyneuropathy

Proteinase 3 anti-neutrophil cytoplasmic antibody (PR3-ANCA) is reported to be highly specific to vasculitis compared to myeloperoxidase (MPO)-ANCA. We report a case of a 19-year-old woman with chronic inflammatory demyelinating polyneuropathy (CIDP) with high PR3-ANCA positivity. The patient respon...

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Detalles Bibliográficos
Autores principales: Kurihara, Masanori, Kurata, Yu, Sugimoto, Izumi, Hatanaka, Yuki, Sakurai, Yasuhisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Letters to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5721574/
https://www.ncbi.nlm.nih.gov/pubmed/29260006
http://dx.doi.org/10.1016/j.ensci.2016.10.001
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author Kurihara, Masanori
Kurata, Yu
Sugimoto, Izumi
Hatanaka, Yuki
Sakurai, Yasuhisa
author_facet Kurihara, Masanori
Kurata, Yu
Sugimoto, Izumi
Hatanaka, Yuki
Sakurai, Yasuhisa
author_sort Kurihara, Masanori
collection PubMed
description Proteinase 3 anti-neutrophil cytoplasmic antibody (PR3-ANCA) is reported to be highly specific to vasculitis compared to myeloperoxidase (MPO)-ANCA. We report a case of a 19-year-old woman with chronic inflammatory demyelinating polyneuropathy (CIDP) with high PR3-ANCA positivity. The patient responded well to intravenous immunoglobulin plus oral steroid, and showed no signs of systemic vasculitis during the subsequent 10 months of follow-up. Our present case suggests that CIDP may accompany high PR3-ANCA levels, which should be differentiated from axonal neuropathy due to vasculitis.
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spelling pubmed-57215742017-12-19 High PR3-ANCA positivity in a patient with chronic inflammatory demyelinating polyneuropathy Kurihara, Masanori Kurata, Yu Sugimoto, Izumi Hatanaka, Yuki Sakurai, Yasuhisa eNeurologicalSci Letters to the Editor Proteinase 3 anti-neutrophil cytoplasmic antibody (PR3-ANCA) is reported to be highly specific to vasculitis compared to myeloperoxidase (MPO)-ANCA. We report a case of a 19-year-old woman with chronic inflammatory demyelinating polyneuropathy (CIDP) with high PR3-ANCA positivity. The patient responded well to intravenous immunoglobulin plus oral steroid, and showed no signs of systemic vasculitis during the subsequent 10 months of follow-up. Our present case suggests that CIDP may accompany high PR3-ANCA levels, which should be differentiated from axonal neuropathy due to vasculitis. Elsevier 2016-10-05 /pmc/articles/PMC5721574/ /pubmed/29260006 http://dx.doi.org/10.1016/j.ensci.2016.10.001 Text en © 2016 The Author(s) http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Letters to the Editor
Kurihara, Masanori
Kurata, Yu
Sugimoto, Izumi
Hatanaka, Yuki
Sakurai, Yasuhisa
High PR3-ANCA positivity in a patient with chronic inflammatory demyelinating polyneuropathy
title High PR3-ANCA positivity in a patient with chronic inflammatory demyelinating polyneuropathy
title_full High PR3-ANCA positivity in a patient with chronic inflammatory demyelinating polyneuropathy
title_fullStr High PR3-ANCA positivity in a patient with chronic inflammatory demyelinating polyneuropathy
title_full_unstemmed High PR3-ANCA positivity in a patient with chronic inflammatory demyelinating polyneuropathy
title_short High PR3-ANCA positivity in a patient with chronic inflammatory demyelinating polyneuropathy
title_sort high pr3-anca positivity in a patient with chronic inflammatory demyelinating polyneuropathy
topic Letters to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5721574/
https://www.ncbi.nlm.nih.gov/pubmed/29260006
http://dx.doi.org/10.1016/j.ensci.2016.10.001
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