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Impaired mixed emotion processing in the right ventrolateral prefrontal cortex in schizophrenia: an fMRI study

BACKGROUND: Schizophrenia has a negative effect on the activity of the temporal and prefrontal cortices in the processing of emotional facial expressions. However no previous research focused on the evaluation of mixed emotions in schizophrenia, albeit they are frequently expressed in everyday situa...

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Autores principales: Szabó, Ádám György, Farkas, Kinga, Marosi, Csilla, Kozák, Lajos R., Rudas, Gábor, Réthelyi, János, Csukly, Gábor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5721596/
https://www.ncbi.nlm.nih.gov/pubmed/29216861
http://dx.doi.org/10.1186/s12888-017-1558-x
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author Szabó, Ádám György
Farkas, Kinga
Marosi, Csilla
Kozák, Lajos R.
Rudas, Gábor
Réthelyi, János
Csukly, Gábor
author_facet Szabó, Ádám György
Farkas, Kinga
Marosi, Csilla
Kozák, Lajos R.
Rudas, Gábor
Réthelyi, János
Csukly, Gábor
author_sort Szabó, Ádám György
collection PubMed
description BACKGROUND: Schizophrenia has a negative effect on the activity of the temporal and prefrontal cortices in the processing of emotional facial expressions. However no previous research focused on the evaluation of mixed emotions in schizophrenia, albeit they are frequently expressed in everyday situations and negative emotions are frequently expressed by mixed facial expressions. METHODS: Altogether 37 subjects, 19 patients with schizophrenia and 18 healthy control subjects were enrolled in the study. The two study groups did not differ in age and education. The stimulus set consisted of 10 fearful (100%), 10 happy (100%), 10 mixed fear (70% fear and 30% happy) and 10 mixed happy facial expressions. During the fMRI acquisition pictures were presented in a randomized order and subjects had to categorize expressions by button press. RESULTS: A decreased activation was found in the patient group during fear, mixed fear and mixed happy processing in the right ventrolateral prefrontal cortex (VLPFC) and the right anterior insula (RAI) at voxel and cluster level after familywise error correction. No difference was found between study groups in activations to happy facial condition. Patients with schizophrenia did not show a differential activation between mixed happy and happy facial expression similar to controls in the right dorsolateral prefrontal cortex (DLPFC). CONCLUSIONS: Patients with schizophrenia showed decreased functioning in right prefrontal regions responsible for salience signaling and valence evaluation during emotion recognition. Our results indicate that fear and mixed happy/fear processing are impaired in schizophrenia, while happy facial expression processing is relatively intact.
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spelling pubmed-57215962017-12-11 Impaired mixed emotion processing in the right ventrolateral prefrontal cortex in schizophrenia: an fMRI study Szabó, Ádám György Farkas, Kinga Marosi, Csilla Kozák, Lajos R. Rudas, Gábor Réthelyi, János Csukly, Gábor BMC Psychiatry Research Article BACKGROUND: Schizophrenia has a negative effect on the activity of the temporal and prefrontal cortices in the processing of emotional facial expressions. However no previous research focused on the evaluation of mixed emotions in schizophrenia, albeit they are frequently expressed in everyday situations and negative emotions are frequently expressed by mixed facial expressions. METHODS: Altogether 37 subjects, 19 patients with schizophrenia and 18 healthy control subjects were enrolled in the study. The two study groups did not differ in age and education. The stimulus set consisted of 10 fearful (100%), 10 happy (100%), 10 mixed fear (70% fear and 30% happy) and 10 mixed happy facial expressions. During the fMRI acquisition pictures were presented in a randomized order and subjects had to categorize expressions by button press. RESULTS: A decreased activation was found in the patient group during fear, mixed fear and mixed happy processing in the right ventrolateral prefrontal cortex (VLPFC) and the right anterior insula (RAI) at voxel and cluster level after familywise error correction. No difference was found between study groups in activations to happy facial condition. Patients with schizophrenia did not show a differential activation between mixed happy and happy facial expression similar to controls in the right dorsolateral prefrontal cortex (DLPFC). CONCLUSIONS: Patients with schizophrenia showed decreased functioning in right prefrontal regions responsible for salience signaling and valence evaluation during emotion recognition. Our results indicate that fear and mixed happy/fear processing are impaired in schizophrenia, while happy facial expression processing is relatively intact. BioMed Central 2017-12-08 /pmc/articles/PMC5721596/ /pubmed/29216861 http://dx.doi.org/10.1186/s12888-017-1558-x Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Szabó, Ádám György
Farkas, Kinga
Marosi, Csilla
Kozák, Lajos R.
Rudas, Gábor
Réthelyi, János
Csukly, Gábor
Impaired mixed emotion processing in the right ventrolateral prefrontal cortex in schizophrenia: an fMRI study
title Impaired mixed emotion processing in the right ventrolateral prefrontal cortex in schizophrenia: an fMRI study
title_full Impaired mixed emotion processing in the right ventrolateral prefrontal cortex in schizophrenia: an fMRI study
title_fullStr Impaired mixed emotion processing in the right ventrolateral prefrontal cortex in schizophrenia: an fMRI study
title_full_unstemmed Impaired mixed emotion processing in the right ventrolateral prefrontal cortex in schizophrenia: an fMRI study
title_short Impaired mixed emotion processing in the right ventrolateral prefrontal cortex in schizophrenia: an fMRI study
title_sort impaired mixed emotion processing in the right ventrolateral prefrontal cortex in schizophrenia: an fmri study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5721596/
https://www.ncbi.nlm.nih.gov/pubmed/29216861
http://dx.doi.org/10.1186/s12888-017-1558-x
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