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Divergent susceptibilities to AAV-SaCas9-gRNA vector-mediated genome-editing in a single-cell-derived cell population

OBJECTIVE: Recombinant adeno-associated virus (AAV)-based vectors are characterized by their robust and safe transgene delivery. The CRISPR/Cas9 and guide RNA (gRNA) system present a promising genome-editing platform, and a recent development of a shorter Cas9 enzyme from Staphylococcus aureus (SaCa...

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Detalles Bibliográficos
Autores principales:	Morsy, Salma G., Tonne, Jason M., Zhu, Yaxi, Lu, Brian, Budzik, Karol, Krempski, James W., Ali, Sherine A., El-Feky, Mohamed A., Ikeda, Yasuhiro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research Note
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5721606/ https://www.ncbi.nlm.nih.gov/pubmed/29221488 http://dx.doi.org/10.1186/s13104-017-3028-4

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