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Oral administration of the 11β-hydroxysteroid-dehydrogenase type 1 inhibitor RO5093151 to patients with glaucoma: an adaptive, randomised, placebo-controlled clinical study

BACKGROUND/AIMS: Cortisol is involved in the regulation of intraocular pressure (IOP). This study aimed to assess the effect of 11β-hydroxysteroid-dehydrogenase type 1 (11βHSD1) inhibition by oral administration of RO5093151 on IOP. METHODS: The exposure of key ocular compartments following oral adm...

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Detalles Bibliográficos
Autores principales:	Schwab, Dietmar, Sturm, Carolina, Portron, Agnès, Fuerst-Recktenwald, Sabine, Hainzl, Dominik, Jordan, Paul, Stewart, William C, Tepedino, Michael E, DuBiner, Harvey
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2017
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5721631/ https://www.ncbi.nlm.nih.gov/pubmed/29354707 http://dx.doi.org/10.1136/bmjophth-2016-000063

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