Kinome and Transcriptome Profiling Reveal Broad and Distinct Activities of Erlotinib, Sunitinib, and Sorafenib in the Mouse Heart and Suggest Cardiotoxicity From Combined Signal Transducer and Activator of Transcription and Epidermal Growth Factor Receptor Inhibition

BACKGROUND: Most novel cancer therapeutics target kinases that are essential to tumor survival. Some of these kinase inhibitors are associated with cardiotoxicity, whereas others appear to be cardiosafe. The basis for this distinction is unclear, as are the molecular effects of kinase inhibitors in...

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Detalles Bibliográficos
Autores principales: Stuhlmiller, Timothy J., Zawistowski, Jon S., Chen, Xin, Sciaky, Noah, Angus, Steven P., Hicks, Sean T., Parry, Traci L., Huang, Wei, Beak, Ju Youn, Willis, Monte S., Johnson, Gary L., Jensen, Brian C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5721866/
https://www.ncbi.nlm.nih.gov/pubmed/29051215
http://dx.doi.org/10.1161/JAHA.117.006635

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