Human Polyomaviruses: The Battle of Large and Small Tumor Antigens

About 40 years ago, the large and small tumor antigens (LT-Ag and sT-Ag) of the polyomavirus (PyVs) simian vacuolating virus 40 have been identified and characterized. To date, it is well known that all the discovered human PyVs (HPyVs) encode these 2 multifunctional and tumorigenic proteins, expres...

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Autores principales: Baez, Camila Freze, Brandão Varella, Rafael, Villani, Sonia, Delbue, Serena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5721967/
https://www.ncbi.nlm.nih.gov/pubmed/29238174
http://dx.doi.org/10.1177/1178122X17744785
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author Baez, Camila Freze
Brandão Varella, Rafael
Villani, Sonia
Delbue, Serena
author_facet Baez, Camila Freze
Brandão Varella, Rafael
Villani, Sonia
Delbue, Serena
author_sort Baez, Camila Freze
collection PubMed
description About 40 years ago, the large and small tumor antigens (LT-Ag and sT-Ag) of the polyomavirus (PyVs) simian vacuolating virus 40 have been identified and characterized. To date, it is well known that all the discovered human PyVs (HPyVs) encode these 2 multifunctional and tumorigenic proteins, expressed at viral replication early stage. The 2 T-Ags are able to transform cells both in vitro and in vivo and seem to play a distinct role in the pathogenesis of some tumors in humans. In addition, they are involved in viral DNA replication, transcription, and virion assembly. This short review focuses on the structural and functional features of the HPyVs’ LT-Ag and sT-Ag, with special attention to their transforming properties.
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spelling pubmed-57219672017-12-13 Human Polyomaviruses: The Battle of Large and Small Tumor Antigens Baez, Camila Freze Brandão Varella, Rafael Villani, Sonia Delbue, Serena Virology (Auckl) Review About 40 years ago, the large and small tumor antigens (LT-Ag and sT-Ag) of the polyomavirus (PyVs) simian vacuolating virus 40 have been identified and characterized. To date, it is well known that all the discovered human PyVs (HPyVs) encode these 2 multifunctional and tumorigenic proteins, expressed at viral replication early stage. The 2 T-Ags are able to transform cells both in vitro and in vivo and seem to play a distinct role in the pathogenesis of some tumors in humans. In addition, they are involved in viral DNA replication, transcription, and virion assembly. This short review focuses on the structural and functional features of the HPyVs’ LT-Ag and sT-Ag, with special attention to their transforming properties. SAGE Publications 2017-12-05 /pmc/articles/PMC5721967/ /pubmed/29238174 http://dx.doi.org/10.1177/1178122X17744785 Text en © The Author(s) 2017 http://www.creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Review
Baez, Camila Freze
Brandão Varella, Rafael
Villani, Sonia
Delbue, Serena
Human Polyomaviruses: The Battle of Large and Small Tumor Antigens
title Human Polyomaviruses: The Battle of Large and Small Tumor Antigens
title_full Human Polyomaviruses: The Battle of Large and Small Tumor Antigens
title_fullStr Human Polyomaviruses: The Battle of Large and Small Tumor Antigens
title_full_unstemmed Human Polyomaviruses: The Battle of Large and Small Tumor Antigens
title_short Human Polyomaviruses: The Battle of Large and Small Tumor Antigens
title_sort human polyomaviruses: the battle of large and small tumor antigens
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5721967/
https://www.ncbi.nlm.nih.gov/pubmed/29238174
http://dx.doi.org/10.1177/1178122X17744785
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