Cargando…

Complication Rates in Posterior Lumbar Interbody Fusion (PLIF) Surgery With Human Bone Morphogenetic Protein 2: Medicare Population

STUDY DESIGN: Retrospective cohort study among Medicare beneficiaries who underwent posterior lumbar interbody fusion (PLIF) surgery. OBJECTIVE: To identify the complication rates associated with the use of bone morphogenetic protein 2 (BMP2) in PLIF. Human BMP2 is commonly used in the “off-label” m...

Descripción completa

Detalles Bibliográficos
Autores principales: Alobaidaan, Raed, Cohen, Jeremiah R., Lord, Elizabeth L., Buser, Zorica, Yoon, S. Tim, Youssef, Jim A., Park, Jong-Beom, Brodke, Darrel S., Wang, Jeffrey C., Meisel, Hans-Joerg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5721992/
https://www.ncbi.nlm.nih.gov/pubmed/29238641
http://dx.doi.org/10.1177/2192568217696695
_version_ 1783284924438020096
author Alobaidaan, Raed
Cohen, Jeremiah R.
Lord, Elizabeth L.
Buser, Zorica
Yoon, S. Tim
Youssef, Jim A.
Park, Jong-Beom
Brodke, Darrel S.
Wang, Jeffrey C.
Meisel, Hans-Joerg
author_facet Alobaidaan, Raed
Cohen, Jeremiah R.
Lord, Elizabeth L.
Buser, Zorica
Yoon, S. Tim
Youssef, Jim A.
Park, Jong-Beom
Brodke, Darrel S.
Wang, Jeffrey C.
Meisel, Hans-Joerg
author_sort Alobaidaan, Raed
collection PubMed
description STUDY DESIGN: Retrospective cohort study among Medicare beneficiaries who underwent posterior lumbar interbody fusion (PLIF) surgery. OBJECTIVE: To identify the complication rates associated with the use of bone morphogenetic protein 2 (BMP2) in PLIF. Human BMP2 is commonly used in the “off-label” manner for various types of spine fusion procedures, including PLIF. However, recent studies have reported potential complications associated with the recombinant human BMP2 (rhBMP2) use in the posterior approach. METHODS: Medicare records within the PearlDiver database were queried for patients undergoing PLIF procedure with and without rhBMP2 between 2005 and 2010. We evaluated complications within 1 year postoperatively. Chi-square was used to compare the complication rates between the 2 groups. RESULTS: A total of 8609 patients underwent PLIF procedure with or without rhBMP2. Individual complication rates in the rhBMP2 group ranged from 0.45% to 7.68% compared with 0.65% to 10.99 in the non-rhBMP2 group. Complication rates for cardiac, pulmonary, lumbosacral neuritis, infection, wound, and urinary tract (include acute kidney failure and post-operative complications) were significantly lower in the rhBMP2 group (P < .05). There was no difference in the rates of central nervous system complications or radiculitis between the 2 groups. CONCLUSION: Our data showed that the patients who received rhBMP2 had lower complication rates compared to the non-rhBMP2 group. However, use of rhBMP2 was associated with a higher rate of pseudarthrosis. We did not observe any difference in radiculitis and central nervous system complications between the groups.
format Online
Article
Text
id pubmed-5721992
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher SAGE Publications
record_format MEDLINE/PubMed
spelling pubmed-57219922017-12-13 Complication Rates in Posterior Lumbar Interbody Fusion (PLIF) Surgery With Human Bone Morphogenetic Protein 2: Medicare Population Alobaidaan, Raed Cohen, Jeremiah R. Lord, Elizabeth L. Buser, Zorica Yoon, S. Tim Youssef, Jim A. Park, Jong-Beom Brodke, Darrel S. Wang, Jeffrey C. Meisel, Hans-Joerg Global Spine J Original Articles STUDY DESIGN: Retrospective cohort study among Medicare beneficiaries who underwent posterior lumbar interbody fusion (PLIF) surgery. OBJECTIVE: To identify the complication rates associated with the use of bone morphogenetic protein 2 (BMP2) in PLIF. Human BMP2 is commonly used in the “off-label” manner for various types of spine fusion procedures, including PLIF. However, recent studies have reported potential complications associated with the recombinant human BMP2 (rhBMP2) use in the posterior approach. METHODS: Medicare records within the PearlDiver database were queried for patients undergoing PLIF procedure with and without rhBMP2 between 2005 and 2010. We evaluated complications within 1 year postoperatively. Chi-square was used to compare the complication rates between the 2 groups. RESULTS: A total of 8609 patients underwent PLIF procedure with or without rhBMP2. Individual complication rates in the rhBMP2 group ranged from 0.45% to 7.68% compared with 0.65% to 10.99 in the non-rhBMP2 group. Complication rates for cardiac, pulmonary, lumbosacral neuritis, infection, wound, and urinary tract (include acute kidney failure and post-operative complications) were significantly lower in the rhBMP2 group (P < .05). There was no difference in the rates of central nervous system complications or radiculitis between the 2 groups. CONCLUSION: Our data showed that the patients who received rhBMP2 had lower complication rates compared to the non-rhBMP2 group. However, use of rhBMP2 was associated with a higher rate of pseudarthrosis. We did not observe any difference in radiculitis and central nervous system complications between the groups. SAGE Publications 2017-05-16 2017-12 /pmc/articles/PMC5721992/ /pubmed/29238641 http://dx.doi.org/10.1177/2192568217696695 Text en © The Author(s) 2017 http://creativecommons.org/licenses/by-nc-nd/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 License (http://www.creativecommons.org/licenses/by-nc-nd/4.0/) which permits non-commercial use, reproduction and distribution of the work as published without adaptation or alteration, without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Original Articles
Alobaidaan, Raed
Cohen, Jeremiah R.
Lord, Elizabeth L.
Buser, Zorica
Yoon, S. Tim
Youssef, Jim A.
Park, Jong-Beom
Brodke, Darrel S.
Wang, Jeffrey C.
Meisel, Hans-Joerg
Complication Rates in Posterior Lumbar Interbody Fusion (PLIF) Surgery With Human Bone Morphogenetic Protein 2: Medicare Population
title Complication Rates in Posterior Lumbar Interbody Fusion (PLIF) Surgery With Human Bone Morphogenetic Protein 2: Medicare Population
title_full Complication Rates in Posterior Lumbar Interbody Fusion (PLIF) Surgery With Human Bone Morphogenetic Protein 2: Medicare Population
title_fullStr Complication Rates in Posterior Lumbar Interbody Fusion (PLIF) Surgery With Human Bone Morphogenetic Protein 2: Medicare Population
title_full_unstemmed Complication Rates in Posterior Lumbar Interbody Fusion (PLIF) Surgery With Human Bone Morphogenetic Protein 2: Medicare Population
title_short Complication Rates in Posterior Lumbar Interbody Fusion (PLIF) Surgery With Human Bone Morphogenetic Protein 2: Medicare Population
title_sort complication rates in posterior lumbar interbody fusion (plif) surgery with human bone morphogenetic protein 2: medicare population
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5721992/
https://www.ncbi.nlm.nih.gov/pubmed/29238641
http://dx.doi.org/10.1177/2192568217696695
work_keys_str_mv AT alobaidaanraed complicationratesinposteriorlumbarinterbodyfusionplifsurgerywithhumanbonemorphogeneticprotein2medicarepopulation
AT cohenjeremiahr complicationratesinposteriorlumbarinterbodyfusionplifsurgerywithhumanbonemorphogeneticprotein2medicarepopulation
AT lordelizabethl complicationratesinposteriorlumbarinterbodyfusionplifsurgerywithhumanbonemorphogeneticprotein2medicarepopulation
AT buserzorica complicationratesinposteriorlumbarinterbodyfusionplifsurgerywithhumanbonemorphogeneticprotein2medicarepopulation
AT yoonstim complicationratesinposteriorlumbarinterbodyfusionplifsurgerywithhumanbonemorphogeneticprotein2medicarepopulation
AT youssefjima complicationratesinposteriorlumbarinterbodyfusionplifsurgerywithhumanbonemorphogeneticprotein2medicarepopulation
AT parkjongbeom complicationratesinposteriorlumbarinterbodyfusionplifsurgerywithhumanbonemorphogeneticprotein2medicarepopulation
AT brodkedarrels complicationratesinposteriorlumbarinterbodyfusionplifsurgerywithhumanbonemorphogeneticprotein2medicarepopulation
AT wangjeffreyc complicationratesinposteriorlumbarinterbodyfusionplifsurgerywithhumanbonemorphogeneticprotein2medicarepopulation
AT meiselhansjoerg complicationratesinposteriorlumbarinterbodyfusionplifsurgerywithhumanbonemorphogeneticprotein2medicarepopulation