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Heart-type fatty acid binding protein levels in elderly diabetics without known cardiovascular disease

BACKGROUND: Cardiovascular disease (CVD) is reported to be higher in elderly diabetics. Serum heart-type fatty acid binding protein (H-FABP) is a serum marker of myocardial ischemia. We aimed to investigate the association between serum H-FABP level and conventional cardiovascular risk factors, infl...

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Autores principales: Beysel, Selvihan, Kizilgul, Muhammed, Ozbek, Mustafa, Caliskan, Mustafa, Kan, Seyfullah, Apaydin, Mahmut, Ozcelik, Ozgur, Cakal, Erman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5722006/
https://www.ncbi.nlm.nih.gov/pubmed/29255351
http://dx.doi.org/10.2147/CIA.S137247
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author Beysel, Selvihan
Kizilgul, Muhammed
Ozbek, Mustafa
Caliskan, Mustafa
Kan, Seyfullah
Apaydin, Mahmut
Ozcelik, Ozgur
Cakal, Erman
author_facet Beysel, Selvihan
Kizilgul, Muhammed
Ozbek, Mustafa
Caliskan, Mustafa
Kan, Seyfullah
Apaydin, Mahmut
Ozcelik, Ozgur
Cakal, Erman
author_sort Beysel, Selvihan
collection PubMed
description BACKGROUND: Cardiovascular disease (CVD) is reported to be higher in elderly diabetics. Serum heart-type fatty acid binding protein (H-FABP) is a serum marker of myocardial ischemia. We aimed to investigate the association between serum H-FABP level and conventional cardiovascular risk factors, inflammatory markers and subclinical atherosclerosis in elderly diabetics without overt CVD. PATIENTS AND METHODS: A total of 50 elderly diabetic patients without overt CVD and 30 age-, sex- and body mass index (BMI)-matched healthy controls were enrolled. Anthropometric and biochemical parameters, serum H-FABP, high-sensitivity C-reactive protein (hs-CRP), fibrinogen and carotid intima-media thickness (CIMT) were measured. Logistic regression analyses (adjustments for age, sex, hypertension, smoking, diabetes, BMI, blood pressure, lipid, blood glucose, hemoglobin A1c, hs-CRP and fibrinogen) were performed to evaluate the association between H-FABP and cardiovascular risk factors and atherosclerosis indices. RESULTS: Serum fibrinogen (421.50±85.52 mg/dL vs 319.17±30.77 mg/dL, p=0.023), CIMT (0.70±0.12 mm vs 0.59±0.06 mm, p<0.001) and hs-CRP (5.72±4.50 mg/dL vs 1.60±0.72 mg/dL, p<0.001) were significantly higher in diabetic patients than controls. The mean serum H-FABP level did not differ between groups (1571.79±604.60 ng/mL vs 1500.25±463.35 ng/mL, p=0.905). H-FABP was positively correlated with fibrinogen (r(2)=0.473, p<0.001), hs-CRP (r(2)=0.323, p=0.003) and CIMT (r(2)=0.467, p<0.001). After full adjustments, the serum H-FABP level was independently associated with an increase in the fibrinogen level (odds ratio [OR] =4.21, 95% confidence level [CI] =1.49–11.90). CONCLUSION: Serum H-FABP was similar in the elderly diabetic patients without known CVD when compared with the nondiabetic control group. H-FABP does not possess a high diagnostic value as a cardiovascular marker when used alone; however, it may add supplementary information in patients with a high fibrinogen level.
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spelling pubmed-57220062017-12-18 Heart-type fatty acid binding protein levels in elderly diabetics without known cardiovascular disease Beysel, Selvihan Kizilgul, Muhammed Ozbek, Mustafa Caliskan, Mustafa Kan, Seyfullah Apaydin, Mahmut Ozcelik, Ozgur Cakal, Erman Clin Interv Aging Original Research BACKGROUND: Cardiovascular disease (CVD) is reported to be higher in elderly diabetics. Serum heart-type fatty acid binding protein (H-FABP) is a serum marker of myocardial ischemia. We aimed to investigate the association between serum H-FABP level and conventional cardiovascular risk factors, inflammatory markers and subclinical atherosclerosis in elderly diabetics without overt CVD. PATIENTS AND METHODS: A total of 50 elderly diabetic patients without overt CVD and 30 age-, sex- and body mass index (BMI)-matched healthy controls were enrolled. Anthropometric and biochemical parameters, serum H-FABP, high-sensitivity C-reactive protein (hs-CRP), fibrinogen and carotid intima-media thickness (CIMT) were measured. Logistic regression analyses (adjustments for age, sex, hypertension, smoking, diabetes, BMI, blood pressure, lipid, blood glucose, hemoglobin A1c, hs-CRP and fibrinogen) were performed to evaluate the association between H-FABP and cardiovascular risk factors and atherosclerosis indices. RESULTS: Serum fibrinogen (421.50±85.52 mg/dL vs 319.17±30.77 mg/dL, p=0.023), CIMT (0.70±0.12 mm vs 0.59±0.06 mm, p<0.001) and hs-CRP (5.72±4.50 mg/dL vs 1.60±0.72 mg/dL, p<0.001) were significantly higher in diabetic patients than controls. The mean serum H-FABP level did not differ between groups (1571.79±604.60 ng/mL vs 1500.25±463.35 ng/mL, p=0.905). H-FABP was positively correlated with fibrinogen (r(2)=0.473, p<0.001), hs-CRP (r(2)=0.323, p=0.003) and CIMT (r(2)=0.467, p<0.001). After full adjustments, the serum H-FABP level was independently associated with an increase in the fibrinogen level (odds ratio [OR] =4.21, 95% confidence level [CI] =1.49–11.90). CONCLUSION: Serum H-FABP was similar in the elderly diabetic patients without known CVD when compared with the nondiabetic control group. H-FABP does not possess a high diagnostic value as a cardiovascular marker when used alone; however, it may add supplementary information in patients with a high fibrinogen level. Dove Medical Press 2017-12-05 /pmc/articles/PMC5722006/ /pubmed/29255351 http://dx.doi.org/10.2147/CIA.S137247 Text en © 2017 Beysel et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Beysel, Selvihan
Kizilgul, Muhammed
Ozbek, Mustafa
Caliskan, Mustafa
Kan, Seyfullah
Apaydin, Mahmut
Ozcelik, Ozgur
Cakal, Erman
Heart-type fatty acid binding protein levels in elderly diabetics without known cardiovascular disease
title Heart-type fatty acid binding protein levels in elderly diabetics without known cardiovascular disease
title_full Heart-type fatty acid binding protein levels in elderly diabetics without known cardiovascular disease
title_fullStr Heart-type fatty acid binding protein levels in elderly diabetics without known cardiovascular disease
title_full_unstemmed Heart-type fatty acid binding protein levels in elderly diabetics without known cardiovascular disease
title_short Heart-type fatty acid binding protein levels in elderly diabetics without known cardiovascular disease
title_sort heart-type fatty acid binding protein levels in elderly diabetics without known cardiovascular disease
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5722006/
https://www.ncbi.nlm.nih.gov/pubmed/29255351
http://dx.doi.org/10.2147/CIA.S137247
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