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A stepping stone in treating dendritic keratitis

PURPOSE: To report the outcome of self-retained amniotic membrane after debridement in recurrent dendritic keratitis. OBSERVATIONS: A 70-year-old female with a recurrent dendritic corneal ulcer received debridement followed by placement of self-retained amniotic membrane. Five days after treatment,...

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Detalles Bibliográficos
Autores principales: Sheha, Hosam, Tighe, Sean, Cheng, Anny M.S., Tseng, Scheffer C.G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5722148/
https://www.ncbi.nlm.nih.gov/pubmed/29260079
http://dx.doi.org/10.1016/j.ajoc.2017.06.002
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author Sheha, Hosam
Tighe, Sean
Cheng, Anny M.S.
Tseng, Scheffer C.G.
author_facet Sheha, Hosam
Tighe, Sean
Cheng, Anny M.S.
Tseng, Scheffer C.G.
author_sort Sheha, Hosam
collection PubMed
description PURPOSE: To report the outcome of self-retained amniotic membrane after debridement in recurrent dendritic keratitis. OBSERVATIONS: A 70-year-old female with a recurrent dendritic corneal ulcer received debridement followed by placement of self-retained amniotic membrane. Five days after treatment, the patient experienced a complete resolution of symptoms, marked reduction of inflammation, complete re-epithelialization of the cornea and improvement of visual acuity. The corneal surface remained stable for 18 months despite noncompliance in using antiviral therapy. CONCLUSIONS AND IMPORTANCE: Self-retained amniotic membrane after debridement appears effective in treating dendritic keratitis. While early debridement is crucial to remove the infected corneal epithelium, amniotic membrane was shown to enhance the healing without scarring or recurrence. Besides the known anti-inflammatory and anti-scarring effects of the amniotic membrane, it may have a potential topical antiviral effect that warrants further investigation.
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spelling pubmed-57221482017-12-19 A stepping stone in treating dendritic keratitis Sheha, Hosam Tighe, Sean Cheng, Anny M.S. Tseng, Scheffer C.G. Am J Ophthalmol Case Rep Case report PURPOSE: To report the outcome of self-retained amniotic membrane after debridement in recurrent dendritic keratitis. OBSERVATIONS: A 70-year-old female with a recurrent dendritic corneal ulcer received debridement followed by placement of self-retained amniotic membrane. Five days after treatment, the patient experienced a complete resolution of symptoms, marked reduction of inflammation, complete re-epithelialization of the cornea and improvement of visual acuity. The corneal surface remained stable for 18 months despite noncompliance in using antiviral therapy. CONCLUSIONS AND IMPORTANCE: Self-retained amniotic membrane after debridement appears effective in treating dendritic keratitis. While early debridement is crucial to remove the infected corneal epithelium, amniotic membrane was shown to enhance the healing without scarring or recurrence. Besides the known anti-inflammatory and anti-scarring effects of the amniotic membrane, it may have a potential topical antiviral effect that warrants further investigation. Elsevier 2017-06-06 /pmc/articles/PMC5722148/ /pubmed/29260079 http://dx.doi.org/10.1016/j.ajoc.2017.06.002 Text en © 2017 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case report
Sheha, Hosam
Tighe, Sean
Cheng, Anny M.S.
Tseng, Scheffer C.G.
A stepping stone in treating dendritic keratitis
title A stepping stone in treating dendritic keratitis
title_full A stepping stone in treating dendritic keratitis
title_fullStr A stepping stone in treating dendritic keratitis
title_full_unstemmed A stepping stone in treating dendritic keratitis
title_short A stepping stone in treating dendritic keratitis
title_sort stepping stone in treating dendritic keratitis
topic Case report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5722148/
https://www.ncbi.nlm.nih.gov/pubmed/29260079
http://dx.doi.org/10.1016/j.ajoc.2017.06.002
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