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Cicatricial ectropion in a patient treated with dupilumab
PURPOSE: To describe a case of bilateral conjunctivitis and cicatricial ectropion associated with dupilumab therapy for atopic dermatitis. OBSERVATIONS: Severe hyperemia of the conjunctiva and eyelid margins, as well as cicatricial ectropion, began two months after starting weekly dupilumab injectio...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5722149/ https://www.ncbi.nlm.nih.gov/pubmed/29260094 http://dx.doi.org/10.1016/j.ajoc.2017.06.017 |
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author | Barnes, Alexander C. Blandford, Alexander D. Perry, Julian D. |
author_facet | Barnes, Alexander C. Blandford, Alexander D. Perry, Julian D. |
author_sort | Barnes, Alexander C. |
collection | PubMed |
description | PURPOSE: To describe a case of bilateral conjunctivitis and cicatricial ectropion associated with dupilumab therapy for atopic dermatitis. OBSERVATIONS: Severe hyperemia of the conjunctiva and eyelid margins, as well as cicatricial ectropion, began two months after starting weekly dupilumab injections for atopic dermatitis. The findings worsened over the next several months and improved after discontinuing dupilumab. CONCLUSIONS AND IMPORTANCE: Dupilumab is a promising intervention in the management of atopic dermatitis and asthma, however, little is known about its potential ocular adverse effects. We report the first case of dupilumab-associated ocular inflammation leading to cicatricial ectropion. |
format | Online Article Text |
id | pubmed-5722149 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-57221492017-12-19 Cicatricial ectropion in a patient treated with dupilumab Barnes, Alexander C. Blandford, Alexander D. Perry, Julian D. Am J Ophthalmol Case Rep Case report PURPOSE: To describe a case of bilateral conjunctivitis and cicatricial ectropion associated with dupilumab therapy for atopic dermatitis. OBSERVATIONS: Severe hyperemia of the conjunctiva and eyelid margins, as well as cicatricial ectropion, began two months after starting weekly dupilumab injections for atopic dermatitis. The findings worsened over the next several months and improved after discontinuing dupilumab. CONCLUSIONS AND IMPORTANCE: Dupilumab is a promising intervention in the management of atopic dermatitis and asthma, however, little is known about its potential ocular adverse effects. We report the first case of dupilumab-associated ocular inflammation leading to cicatricial ectropion. Elsevier 2017-06-22 /pmc/articles/PMC5722149/ /pubmed/29260094 http://dx.doi.org/10.1016/j.ajoc.2017.06.017 Text en © 2017 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Case report Barnes, Alexander C. Blandford, Alexander D. Perry, Julian D. Cicatricial ectropion in a patient treated with dupilumab |
title | Cicatricial ectropion in a patient treated with dupilumab |
title_full | Cicatricial ectropion in a patient treated with dupilumab |
title_fullStr | Cicatricial ectropion in a patient treated with dupilumab |
title_full_unstemmed | Cicatricial ectropion in a patient treated with dupilumab |
title_short | Cicatricial ectropion in a patient treated with dupilumab |
title_sort | cicatricial ectropion in a patient treated with dupilumab |
topic | Case report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5722149/ https://www.ncbi.nlm.nih.gov/pubmed/29260094 http://dx.doi.org/10.1016/j.ajoc.2017.06.017 |
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