Cargando…

Cicatricial ectropion in a patient treated with dupilumab

PURPOSE: To describe a case of bilateral conjunctivitis and cicatricial ectropion associated with dupilumab therapy for atopic dermatitis. OBSERVATIONS: Severe hyperemia of the conjunctiva and eyelid margins, as well as cicatricial ectropion, began two months after starting weekly dupilumab injectio...

Descripción completa

Detalles Bibliográficos
Autores principales: Barnes, Alexander C., Blandford, Alexander D., Perry, Julian D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5722149/
https://www.ncbi.nlm.nih.gov/pubmed/29260094
http://dx.doi.org/10.1016/j.ajoc.2017.06.017
_version_ 1783284960087506944
author Barnes, Alexander C.
Blandford, Alexander D.
Perry, Julian D.
author_facet Barnes, Alexander C.
Blandford, Alexander D.
Perry, Julian D.
author_sort Barnes, Alexander C.
collection PubMed
description PURPOSE: To describe a case of bilateral conjunctivitis and cicatricial ectropion associated with dupilumab therapy for atopic dermatitis. OBSERVATIONS: Severe hyperemia of the conjunctiva and eyelid margins, as well as cicatricial ectropion, began two months after starting weekly dupilumab injections for atopic dermatitis. The findings worsened over the next several months and improved after discontinuing dupilumab. CONCLUSIONS AND IMPORTANCE: Dupilumab is a promising intervention in the management of atopic dermatitis and asthma, however, little is known about its potential ocular adverse effects. We report the first case of dupilumab-associated ocular inflammation leading to cicatricial ectropion.
format Online
Article
Text
id pubmed-5722149
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-57221492017-12-19 Cicatricial ectropion in a patient treated with dupilumab Barnes, Alexander C. Blandford, Alexander D. Perry, Julian D. Am J Ophthalmol Case Rep Case report PURPOSE: To describe a case of bilateral conjunctivitis and cicatricial ectropion associated with dupilumab therapy for atopic dermatitis. OBSERVATIONS: Severe hyperemia of the conjunctiva and eyelid margins, as well as cicatricial ectropion, began two months after starting weekly dupilumab injections for atopic dermatitis. The findings worsened over the next several months and improved after discontinuing dupilumab. CONCLUSIONS AND IMPORTANCE: Dupilumab is a promising intervention in the management of atopic dermatitis and asthma, however, little is known about its potential ocular adverse effects. We report the first case of dupilumab-associated ocular inflammation leading to cicatricial ectropion. Elsevier 2017-06-22 /pmc/articles/PMC5722149/ /pubmed/29260094 http://dx.doi.org/10.1016/j.ajoc.2017.06.017 Text en © 2017 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case report
Barnes, Alexander C.
Blandford, Alexander D.
Perry, Julian D.
Cicatricial ectropion in a patient treated with dupilumab
title Cicatricial ectropion in a patient treated with dupilumab
title_full Cicatricial ectropion in a patient treated with dupilumab
title_fullStr Cicatricial ectropion in a patient treated with dupilumab
title_full_unstemmed Cicatricial ectropion in a patient treated with dupilumab
title_short Cicatricial ectropion in a patient treated with dupilumab
title_sort cicatricial ectropion in a patient treated with dupilumab
topic Case report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5722149/
https://www.ncbi.nlm.nih.gov/pubmed/29260094
http://dx.doi.org/10.1016/j.ajoc.2017.06.017
work_keys_str_mv AT barnesalexanderc cicatricialectropioninapatienttreatedwithdupilumab
AT blandfordalexanderd cicatricialectropioninapatienttreatedwithdupilumab
AT perryjuliand cicatricialectropioninapatienttreatedwithdupilumab