A synthetic intrabody based selective and generic inhibitor of GPCR endocytosis

β-arrestins (βarrs) critically mediate desensitization, endocytosis and signaling of G Protein-Coupled Receptors (GPCRs), and they scaffold a large number of interaction partners. However, allosteric modulation of their scaffolding abilities and direct targeting of their interaction interfaces to se...

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Detalles Bibliográficos
Autores principales: Ghosh, Eshan, Srivastava, Ashish, Baidya, Mithu, Kumari, Punita, Dwivedi, Hemlata, Nidhi, Kumari, Ranjan, Ravi, Dogra, Shalini, Koide, Akiko, Yadav, Prem N., Sidhu, Sachdev S., Koide, Shohei, Shukla, Arun K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5722207/
https://www.ncbi.nlm.nih.gov/pubmed/28967893
http://dx.doi.org/10.1038/nnano.2017.188

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