Cargando…

Desethylamiodarone—A metabolite of amiodarone—Induces apoptosis on T24 human bladder cancer cells via multiple pathways

Bladder cancer (BC) is a common malignancy of the urinary tract that has a higher frequency in men than in women. Cytostatic resistance and metastasis formation are significant risk factors in BC therapy; therefore, there is great interest in overcoming drug resistance and in initiating research for...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bognar, Zita, Fekete, Katalin, Antus, Csenge, Hocsak, Eniko, Bognar, Rita, Tapodi, Antal, Boronkai, Arpad, Farkas, Nelli, Gallyas, Ferenc, Sumegi, Balazs, Szanto, Arpad
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5722307/ https://www.ncbi.nlm.nih.gov/pubmed/29220397 http://dx.doi.org/10.1371/journal.pone.0189470

Ejemplares similares

Amiodarone’s major metabolite, desethylamiodarone inhibits proliferation of B16-F10 melanoma cells and limits lung metastasis formation in an in vivo experimental model
por: Bognar, Zita, et al.
Publicado: (2020)

Involvement of Mitochondrial Mechanisms and Cyclooxygenase-2 Activation in the Effect of Desethylamiodarone on 4T1 Triple-Negative Breast Cancer Line
por: Gallyas, Ferenc, et al.
Publicado: (2022)

BGP-15 Protects against Oxidative Stress- or Lipopolysaccharide-Induced Mitochondrial Destabilization and Reduces Mitochondrial Production of Reactive Oxygen Species
por: Sumegi, Katalin, et al.
Publicado: (2017)

Involvement of Mitochondrial Mechanisms in the Cytostatic Effect of Desethylamiodarone in B16F10 Melanoma Cells
por: Ramadan, Fadi H. J., et al.
Publicado: (2020)

Thymic Atrophy and Apoptosis of CD4(+)CD8(+) Thymocytes in the Cuprizone Model of Multiple Sclerosis
por: Solti, Izabella, et al.
Publicado: (2015)

Correlation between the progressive cytoplasmic expression of a novel small heat shock protein (Hsp16.2) and malignancy in brain tumors
por: Pozsgai, Eva, et al.
Publicado: (2007)

Role of Mitochondrial Network Stabilisation by a Human Small Heat Shock Protein in Tumour Malignancy
por: Turi, Zsuzsanna, et al.
Publicado: (2015)

Effects of Amiodarone and N-desethylamiodarone on Cardiac Voltage-Gated Sodium Channels
por: Ghovanloo, Mohammad-Reza, et al.
Publicado: (2016)

Antioxidant and Anti-Inflammatory Effects in RAW264.7 Macrophages of Malvidin, a Major Red Wine Polyphenol
por: Bognar, Eszter, et al.
Publicado: (2013)

Protective effect of the poly(ADP-ribose) polymerase inhibitor PJ34 on mitochondrial depolarization-mediated cell death in hepatocellular carcinoma cells involves attenuation of c-Jun N-terminal kinase-2 and protein kinase B/Akt activation
por: Radnai, Balazs, et al.
Publicado: (2012)

Cyclophilin D‐dependent mitochondrial permeability transition amplifies inflammatory reprogramming in endotoxemia
por: Veres, Balazs, et al.
Publicado: (2021)

Mitochondrial Protection by PARP Inhibition
por: Gallyas Jr., Ferenc, et al.
Publicado: (2020)

Syntheses and Study of a Pyrroline Nitroxide Condensed Phospholene Oxide and a Pyrroline Nitroxide Attached Diphenylphosphine
por: Isbera, Mostafa, et al.
Publicado: (2021)

Therapeutic monitoring of amiodarone and desethylamiodarone after surgical ablation of atrial fibrillation-evaluation of the relationship between clinical effect and the serum concentration()
por: Hrudikova, Erika, et al.
Publicado: (2021)

Role of Akt Activation in PARP Inhibitor Resistance in Cancer
por: Gallyas, Ferenc, et al.
Publicado: (2020)

PARP Inhibition Attenuates Acute Kidney Allograft Rejection by Suppressing Cell Death Pathways and Activating PI-3K-Akt Cascade
por: Kalmar-Nagy, Karoly, et al.
Publicado: (2013)

Chronic PARP-1 inhibition reduces carotid vessel remodeling and oxidative damage of the dorsal hippocampus in spontaneously hypertensive rats
por: Eros, Krisztian, et al.
Publicado: (2017)

Cytostatic Effect of a Novel Mitochondria-Targeted Pyrroline Nitroxide in Human Breast Cancer Lines
por: Andreidesz, Kitti, et al.
Publicado: (2021)

BGP-15 Protects against Heart Failure by Enhanced Mitochondrial Biogenesis and Decreased Fibrotic Remodelling in Spontaneously Hypertensive Rats
por: Horvath, Orsolya, et al.
Publicado: (2021)

Remodeling of Liver and Plasma Lipidomes in Mice Lacking Cyclophilin D
por: Koszegi, Balazs, et al.
Publicado: (2022)

Effective chemotherapy and targeted therapy supplemented with stereotactic radiotherapy of a patient with metastatic colon cancer following renal transplantation: a case report
por: Bellyei, Szabolcs, et al.
Publicado: (2021)

Altered Immune Response and Implantation Failure in Progesterone-Induced Blocking Factor-Deficient Mice
por: Csabai, Timea, et al.
Publicado: (2020)

The Mitochondrial Targets of Neuroprotective Drug Vinpocetine on Primary Neuron Cultures, Brain Capillary Endothelial Cells, Synaptosomes, and Brain Mitochondria
por: Svab, Gergely, et al.
Publicado: (2019)

Mitochondrial sequence diversity reveals the hybrid origin of invasive gibel carp (Carassius gibelio) populations in Hungary
por: Keszte, Szilvia, et al.
Publicado: (2021)

Novel Mechanisms of Sildenafil in Pulmonary Hypertension Involving Cytokines/Chemokines, MAP Kinases and Akt
por: Kiss, Tamas, et al.
Publicado: (2014)

Shorter headed dogs, visually cooperative breeds, younger and playful dogs form eye contact faster with an unfamiliar human
por: Bognár, Zsófia, et al.
Publicado: (2021)

Simulation of the effect of mucociliary clearance on the bronchial distribution of inhaled radon progenies and related cellular damage using a new deposition and clearance model for the lung
por: Farkas, Árpád
Publicado: (2020)

A simple and rapid flow cytometry-based assay to identify a competent embryo prior to embryo transfer
por: Pallinger, Eva, et al.
Publicado: (2017)

Enhancing Molecular Testing for Effective Delivery of Actionable Gene Diagnostics
por: Kovács, Árpád Ferenc, et al.
Publicado: (2022)

The difference between two brachycephalic and one mesocephalic dog breeds’ problem-solving performance suggests evidence for paedomorphism in behaviour
por: Ujfalussy, Dorottya Júlia, et al.
Publicado: (2023)

PARP Inhibitor PJ34 Protects Mitochondria and Induces DNA-Damage Mediated Apoptosis in Combination With Cisplatin or Temozolomide in B16F10 Melanoma Cells
por: Cseh, Anna Maria, et al.
Publicado: (2019)

Adaptation and validation of the Hungarian version of Thyroid-Related Patient-Reported Outcome-39 (ThyPro-39) questionnaire: testing factor structure, known-group validity with the comparison of quality of life in Hashimoto’s thyroiditis and Graves’ disease
por: Rigó, Adrien, et al.
Publicado: (2023)

Epigenetics of Meningiomas
por: Murnyák, Balázs, et al.
Publicado: (2015)

Phase-Selective Synthesis of Anatase and Rutile TiO(2) Nanocrystals and Their Impacts on Grapevine Leaves: Accumulation of Mineral Nutrients and Triggering the Plant Defense
por: Kőrösi, László, et al.
Publicado: (2022)

Indefinite inner product spaces
por: Bognár, Janós
Publicado: (1974)

Palliative Care: A Primary Care Pharmacist Perspective
por: Bognar, Julia
Publicado: (2022)

Alteration of Tight and Adherens Junctions on 50-Hz Magnetic Field Exposure in Madin Darby Canine Kidney (MDCK) Cells
por: Somosy, Zoltán, et al.
Publicado: (2004)

Medication Adherence and Healthcare Utilization in Relapsing-Remitting Multiple Sclerosis Patients Using Teriflunomide
por: Greene, Nupur, et al.
Publicado: (2022)

Sleep-physiological correlates of brachycephaly in dogs
por: Iotchev, Ivaylo Borislavov, et al.
Publicado: (2023)

PARP-Inhibitor Treatment Prevents Hypertension Induced Cardiac Remodeling by Favorable Modulation of Heat Shock Proteins, Akt-1/GSK-3β and Several PKC Isoforms
por: Deres, Laszlo, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_4d418mirmb4dhasfgelhhnuegg