Substitutions of PrP N-terminal histidine residues modulate scrapie disease pathogenesis and incubation time in transgenic mice

Prion diseases have been linked to impaired copper homeostasis and copper induced-oxidative damage to the brain. Divalent metal ions, such as Cu(2+) and Zn(2+), bind to cellular prion protein (PrP(C)) at octapeptide repeat (OR) and non-OR sites within the N-terminal half of the protein but informati...

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Detalles Bibliográficos
Autores principales: Eigenbrod, Sabina, Frick, Petra, Bertsch, Uwe, Mitteregger-Kretzschmar, Gerda, Mielke, Janina, Maringer, Marko, Piening, Niklas, Hepp, Alexander, Daude, Nathalie, Windl, Otto, Levin, Johannes, Giese, Armin, Sakthivelu, Vignesh, Tatzelt, Jörg, Kretzschmar, Hans, Westaway, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5722314/
https://www.ncbi.nlm.nih.gov/pubmed/29220360
http://dx.doi.org/10.1371/journal.pone.0188989

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