C5a and C5aR are elevated in joints of rheumatoid and psoriatic arthritis patients, and C5aR blockade attenuates leukocyte migration to synovial fluid

Complement activation correlates to rheumatoid arthritis disease activity, and increased amounts of the complement split product C5a is observed in synovial fluids from rheumatoid arthritis patients. Blockade of C5a or its receptor (C5aR) is efficacious in several arthritis models. The aim of this s...

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Detalles Bibliográficos
Autores principales: Hornum, Lars, Hansen, Anker Jon, Tornehave, Ditte, Fjording, Marianne Scheel, Colmenero, Paula, Wätjen, Inger Falbe, Søe Nielsen, Niels Henrik, Bliddal, Henning, Bartels, Else Marie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5722346/
https://www.ncbi.nlm.nih.gov/pubmed/29220376
http://dx.doi.org/10.1371/journal.pone.0189017

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