Cargando…

Dosimetric evaluation of a newly designed low dose rate brachytherapy applicator for treatment of cervical cancer with extension into the lower vagina

Currently, patients having cervical cancer with extension into the lower vagina are being treated with a combination of the Fletcher–Suit applicator, which treats the cervix, and a vaginal cylinder, which treats the lower vagina. With this method, patients receive two separate implants—a procedure t...

Descripción completa

Detalles Bibliográficos
Autores principales: Baker, Curtis, Dini, Sharifeh A., Kudrimoti, Mahesh, Awan, Shahid B., Meigooni, Ali S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5722412/
https://www.ncbi.nlm.nih.gov/pubmed/17592462
http://dx.doi.org/10.1120/jacmp.v8i2.2400
_version_ 1783285008065101824
author Baker, Curtis
Dini, Sharifeh A.
Kudrimoti, Mahesh
Awan, Shahid B.
Meigooni, Ali S.
author_facet Baker, Curtis
Dini, Sharifeh A.
Kudrimoti, Mahesh
Awan, Shahid B.
Meigooni, Ali S.
author_sort Baker, Curtis
collection PubMed
description Currently, patients having cervical cancer with extension into the lower vagina are being treated with a combination of the Fletcher–Suit applicator, which treats the cervix, and a vaginal cylinder, which treats the lower vagina. With this method, patients receive two separate implants—a procedure that creates greater uncertainty in the dose distribution and unnecessary patient inconvenience. To reduce the uncertainty of the dose delivery and to eliminate patient inconvenience, a new applicator was designed and fabricated at the University of Kentucky for treatment of cervical cancer extending into the lower vagina. In addition, the geometric design of the new device allows for treatment of cervical cancer without extension into the lower vagina and simultaneously provides advantages relative to the commonly used Fletcher–Suit applicator. The dosimetric characteristics of this new applicator (hereafter called Meigooni applicator) were determined using experimental procedures. The measurements were performed using tissue‐equivalent phantom material (Solid Water: Gammex RMI, Middleton, WI) that was machined to accommodate the applicator and LiF thermoluminescent dosimetry chips. The applicator was loaded with [Formula: see text] brachytherapy sources in a standard loading scheme. A similar experimental procedure was performed using the currently available Fletcher–Suit mini‐ovoid applicator. The results obtained with each applicator were compared with the values calculated by two commercially available treatment planning systems. The experiments showed that the Meigooni applicator allows for safe single treatment of cervical cancer that has extended into the lower vagina, eliminating the need for two separate treatment techniques. Moreover, the Meigooni applicator can function as an alternative to the Fletcher–Suit applicator for the treatment of patients with cervical cancer. PACS number: 87.53.Jw
format Online
Article
Text
id pubmed-5722412
institution National Center for Biotechnology Information
language English
publishDate 2007
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-57224122018-04-02 Dosimetric evaluation of a newly designed low dose rate brachytherapy applicator for treatment of cervical cancer with extension into the lower vagina Baker, Curtis Dini, Sharifeh A. Kudrimoti, Mahesh Awan, Shahid B. Meigooni, Ali S. J Appl Clin Med Phys Radiation Oncology Physics Currently, patients having cervical cancer with extension into the lower vagina are being treated with a combination of the Fletcher–Suit applicator, which treats the cervix, and a vaginal cylinder, which treats the lower vagina. With this method, patients receive two separate implants—a procedure that creates greater uncertainty in the dose distribution and unnecessary patient inconvenience. To reduce the uncertainty of the dose delivery and to eliminate patient inconvenience, a new applicator was designed and fabricated at the University of Kentucky for treatment of cervical cancer extending into the lower vagina. In addition, the geometric design of the new device allows for treatment of cervical cancer without extension into the lower vagina and simultaneously provides advantages relative to the commonly used Fletcher–Suit applicator. The dosimetric characteristics of this new applicator (hereafter called Meigooni applicator) were determined using experimental procedures. The measurements were performed using tissue‐equivalent phantom material (Solid Water: Gammex RMI, Middleton, WI) that was machined to accommodate the applicator and LiF thermoluminescent dosimetry chips. The applicator was loaded with [Formula: see text] brachytherapy sources in a standard loading scheme. A similar experimental procedure was performed using the currently available Fletcher–Suit mini‐ovoid applicator. The results obtained with each applicator were compared with the values calculated by two commercially available treatment planning systems. The experiments showed that the Meigooni applicator allows for safe single treatment of cervical cancer that has extended into the lower vagina, eliminating the need for two separate treatment techniques. Moreover, the Meigooni applicator can function as an alternative to the Fletcher–Suit applicator for the treatment of patients with cervical cancer. PACS number: 87.53.Jw John Wiley and Sons Inc. 2007-04-19 /pmc/articles/PMC5722412/ /pubmed/17592462 http://dx.doi.org/10.1120/jacmp.v8i2.2400 Text en © 2007 The Authors. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/3.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Radiation Oncology Physics
Baker, Curtis
Dini, Sharifeh A.
Kudrimoti, Mahesh
Awan, Shahid B.
Meigooni, Ali S.
Dosimetric evaluation of a newly designed low dose rate brachytherapy applicator for treatment of cervical cancer with extension into the lower vagina
title Dosimetric evaluation of a newly designed low dose rate brachytherapy applicator for treatment of cervical cancer with extension into the lower vagina
title_full Dosimetric evaluation of a newly designed low dose rate brachytherapy applicator for treatment of cervical cancer with extension into the lower vagina
title_fullStr Dosimetric evaluation of a newly designed low dose rate brachytherapy applicator for treatment of cervical cancer with extension into the lower vagina
title_full_unstemmed Dosimetric evaluation of a newly designed low dose rate brachytherapy applicator for treatment of cervical cancer with extension into the lower vagina
title_short Dosimetric evaluation of a newly designed low dose rate brachytherapy applicator for treatment of cervical cancer with extension into the lower vagina
title_sort dosimetric evaluation of a newly designed low dose rate brachytherapy applicator for treatment of cervical cancer with extension into the lower vagina
topic Radiation Oncology Physics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5722412/
https://www.ncbi.nlm.nih.gov/pubmed/17592462
http://dx.doi.org/10.1120/jacmp.v8i2.2400
work_keys_str_mv AT bakercurtis dosimetricevaluationofanewlydesignedlowdoseratebrachytherapyapplicatorfortreatmentofcervicalcancerwithextensionintothelowervagina
AT dinisharifeha dosimetricevaluationofanewlydesignedlowdoseratebrachytherapyapplicatorfortreatmentofcervicalcancerwithextensionintothelowervagina
AT kudrimotimahesh dosimetricevaluationofanewlydesignedlowdoseratebrachytherapyapplicatorfortreatmentofcervicalcancerwithextensionintothelowervagina
AT awanshahidb dosimetricevaluationofanewlydesignedlowdoseratebrachytherapyapplicatorfortreatmentofcervicalcancerwithextensionintothelowervagina
AT meigoonialis dosimetricevaluationofanewlydesignedlowdoseratebrachytherapyapplicatorfortreatmentofcervicalcancerwithextensionintothelowervagina