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MAGIC polymer gel for dosimetric verification in boron neutron capture therapy
Radiation‐sensitive polymer gels are among the most promising three‐dimensional dose verification tools developed to date. We tested the normoxic polymer gel dosimeter known by the acronym MAGIC (methacrylic and ascorbic acid in gelatin initiated by copper) to evaluate its use in boron neutron captu...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2007
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5722414/ https://www.ncbi.nlm.nih.gov/pubmed/17592463 http://dx.doi.org/10.1120/jacmp.v8i2.2409 |
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author | Uusi–Simola, Jouni Heikkinen, Sami Kotiluoto, Petri Serén, Tom Seppälä, Tiina Auterinen, Iiro Savolainen, Sauli |
author_facet | Uusi–Simola, Jouni Heikkinen, Sami Kotiluoto, Petri Serén, Tom Seppälä, Tiina Auterinen, Iiro Savolainen, Sauli |
author_sort | Uusi–Simola, Jouni |
collection | PubMed |
description | Radiation‐sensitive polymer gels are among the most promising three‐dimensional dose verification tools developed to date. We tested the normoxic polymer gel dosimeter known by the acronym MAGIC (methacrylic and ascorbic acid in gelatin initiated by copper) to evaluate its use in boron neutron capture therapy (BNCT) dosimetry. We irradiated a large cylindrical gel phantom (diameter: 10 cm; length: 20 cm) in the epithermal neutron beam of the Finnish BNCT facility at the FiR 1 nuclear reactor. Neutron irradiation was simulated with a Monte Carlo radiation transport code MCNP. To compare dose–response, gel samples from the same production batch were also irradiated with 6 MV photons from a medical linear accelerator. Irradiated gel phantoms then underwent magnetic resonance imaging to determine their R2 relaxation rate maps. The measured and normalized dose distribution in the epithermal neutron beam was compared with the dose distribution calculated by computer simulation. The results support the feasibility of using MAGIC gel in BNCT dosimetry. PACS numbers: 87.53.Qc, 87.53.Wz, 87.66.Ff |
format | Online Article Text |
id | pubmed-5722414 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2007 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-57224142018-04-02 MAGIC polymer gel for dosimetric verification in boron neutron capture therapy Uusi–Simola, Jouni Heikkinen, Sami Kotiluoto, Petri Serén, Tom Seppälä, Tiina Auterinen, Iiro Savolainen, Sauli J Appl Clin Med Phys Radiation Measurements Radiation‐sensitive polymer gels are among the most promising three‐dimensional dose verification tools developed to date. We tested the normoxic polymer gel dosimeter known by the acronym MAGIC (methacrylic and ascorbic acid in gelatin initiated by copper) to evaluate its use in boron neutron capture therapy (BNCT) dosimetry. We irradiated a large cylindrical gel phantom (diameter: 10 cm; length: 20 cm) in the epithermal neutron beam of the Finnish BNCT facility at the FiR 1 nuclear reactor. Neutron irradiation was simulated with a Monte Carlo radiation transport code MCNP. To compare dose–response, gel samples from the same production batch were also irradiated with 6 MV photons from a medical linear accelerator. Irradiated gel phantoms then underwent magnetic resonance imaging to determine their R2 relaxation rate maps. The measured and normalized dose distribution in the epithermal neutron beam was compared with the dose distribution calculated by computer simulation. The results support the feasibility of using MAGIC gel in BNCT dosimetry. PACS numbers: 87.53.Qc, 87.53.Wz, 87.66.Ff John Wiley and Sons Inc. 2007-04-30 /pmc/articles/PMC5722414/ /pubmed/17592463 http://dx.doi.org/10.1120/jacmp.v8i2.2409 Text en © 2007 The Authors. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/3.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Radiation Measurements Uusi–Simola, Jouni Heikkinen, Sami Kotiluoto, Petri Serén, Tom Seppälä, Tiina Auterinen, Iiro Savolainen, Sauli MAGIC polymer gel for dosimetric verification in boron neutron capture therapy |
title | MAGIC polymer gel for dosimetric verification in boron neutron capture therapy |
title_full | MAGIC polymer gel for dosimetric verification in boron neutron capture therapy |
title_fullStr | MAGIC polymer gel for dosimetric verification in boron neutron capture therapy |
title_full_unstemmed | MAGIC polymer gel for dosimetric verification in boron neutron capture therapy |
title_short | MAGIC polymer gel for dosimetric verification in boron neutron capture therapy |
title_sort | magic polymer gel for dosimetric verification in boron neutron capture therapy |
topic | Radiation Measurements |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5722414/ https://www.ncbi.nlm.nih.gov/pubmed/17592463 http://dx.doi.org/10.1120/jacmp.v8i2.2409 |
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