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MAGIC polymer gel for dosimetric verification in boron neutron capture therapy

Radiation‐sensitive polymer gels are among the most promising three‐dimensional dose verification tools developed to date. We tested the normoxic polymer gel dosimeter known by the acronym MAGIC (methacrylic and ascorbic acid in gelatin initiated by copper) to evaluate its use in boron neutron captu...

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Autores principales: Uusi–Simola, Jouni, Heikkinen, Sami, Kotiluoto, Petri, Serén, Tom, Seppälä, Tiina, Auterinen, Iiro, Savolainen, Sauli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5722414/
https://www.ncbi.nlm.nih.gov/pubmed/17592463
http://dx.doi.org/10.1120/jacmp.v8i2.2409
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author Uusi–Simola, Jouni
Heikkinen, Sami
Kotiluoto, Petri
Serén, Tom
Seppälä, Tiina
Auterinen, Iiro
Savolainen, Sauli
author_facet Uusi–Simola, Jouni
Heikkinen, Sami
Kotiluoto, Petri
Serén, Tom
Seppälä, Tiina
Auterinen, Iiro
Savolainen, Sauli
author_sort Uusi–Simola, Jouni
collection PubMed
description Radiation‐sensitive polymer gels are among the most promising three‐dimensional dose verification tools developed to date. We tested the normoxic polymer gel dosimeter known by the acronym MAGIC (methacrylic and ascorbic acid in gelatin initiated by copper) to evaluate its use in boron neutron capture therapy (BNCT) dosimetry. We irradiated a large cylindrical gel phantom (diameter: 10 cm; length: 20 cm) in the epithermal neutron beam of the Finnish BNCT facility at the FiR 1 nuclear reactor. Neutron irradiation was simulated with a Monte Carlo radiation transport code MCNP. To compare dose–response, gel samples from the same production batch were also irradiated with 6 MV photons from a medical linear accelerator. Irradiated gel phantoms then underwent magnetic resonance imaging to determine their R2 relaxation rate maps. The measured and normalized dose distribution in the epithermal neutron beam was compared with the dose distribution calculated by computer simulation. The results support the feasibility of using MAGIC gel in BNCT dosimetry. PACS numbers: 87.53.Qc, 87.53.Wz, 87.66.Ff
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spelling pubmed-57224142018-04-02 MAGIC polymer gel for dosimetric verification in boron neutron capture therapy Uusi–Simola, Jouni Heikkinen, Sami Kotiluoto, Petri Serén, Tom Seppälä, Tiina Auterinen, Iiro Savolainen, Sauli J Appl Clin Med Phys Radiation Measurements Radiation‐sensitive polymer gels are among the most promising three‐dimensional dose verification tools developed to date. We tested the normoxic polymer gel dosimeter known by the acronym MAGIC (methacrylic and ascorbic acid in gelatin initiated by copper) to evaluate its use in boron neutron capture therapy (BNCT) dosimetry. We irradiated a large cylindrical gel phantom (diameter: 10 cm; length: 20 cm) in the epithermal neutron beam of the Finnish BNCT facility at the FiR 1 nuclear reactor. Neutron irradiation was simulated with a Monte Carlo radiation transport code MCNP. To compare dose–response, gel samples from the same production batch were also irradiated with 6 MV photons from a medical linear accelerator. Irradiated gel phantoms then underwent magnetic resonance imaging to determine their R2 relaxation rate maps. The measured and normalized dose distribution in the epithermal neutron beam was compared with the dose distribution calculated by computer simulation. The results support the feasibility of using MAGIC gel in BNCT dosimetry. PACS numbers: 87.53.Qc, 87.53.Wz, 87.66.Ff John Wiley and Sons Inc. 2007-04-30 /pmc/articles/PMC5722414/ /pubmed/17592463 http://dx.doi.org/10.1120/jacmp.v8i2.2409 Text en © 2007 The Authors. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/3.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Radiation Measurements
Uusi–Simola, Jouni
Heikkinen, Sami
Kotiluoto, Petri
Serén, Tom
Seppälä, Tiina
Auterinen, Iiro
Savolainen, Sauli
MAGIC polymer gel for dosimetric verification in boron neutron capture therapy
title MAGIC polymer gel for dosimetric verification in boron neutron capture therapy
title_full MAGIC polymer gel for dosimetric verification in boron neutron capture therapy
title_fullStr MAGIC polymer gel for dosimetric verification in boron neutron capture therapy
title_full_unstemmed MAGIC polymer gel for dosimetric verification in boron neutron capture therapy
title_short MAGIC polymer gel for dosimetric verification in boron neutron capture therapy
title_sort magic polymer gel for dosimetric verification in boron neutron capture therapy
topic Radiation Measurements
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5722414/
https://www.ncbi.nlm.nih.gov/pubmed/17592463
http://dx.doi.org/10.1120/jacmp.v8i2.2409
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