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Extracranial doses in stereotactic and conventional radiotherapy for pituitary adenomas

The purpose of this study is to determine the extracranial dose in patients treated for pituitary adenoma with conventional and stereotactic radiotherapy (SRT). Twelve patients receiving treatment with radiation for pituitary adenoma were selected. Six patients underwent SRT, and six patients underw...

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Detalles Bibliográficos
Autores principales: Ram, Thomas Samuel, Ravindran, Paul B., Viswanathan, Faith R., Viswanathan, Perungulam Narayan, Pavamani, Simon P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5722438/
https://www.ncbi.nlm.nih.gov/pubmed/17533326
http://dx.doi.org/10.1120/jacmp.v7i2.2203
Descripción
Sumario:The purpose of this study is to determine the extracranial dose in patients treated for pituitary adenoma with conventional and stereotactic radiotherapy (SRT). Twelve patients receiving treatment with radiation for pituitary adenoma were selected. Six patients underwent SRT, and six patients underwent conventional radiotherapy. Extracranial doses were measured with pre‐irradiation annealed lithium fluoride thermoluminscent dosimetry (TLD) chips. The chips were wrapped and placed on the patients’ skin, over each eyelid, the thyroid, chest, and scrotum for males and over the suprapubic region for females. Postradiation annealing was done, and the TLDs were read in a TLD reader system. The results were analyzed using the Wilcoxon matched‐pairs signed rank test by SPSS, version 6.01. The doses to the thyroid, center, and gonads were significantly higher ([Formula: see text] , [Formula: see text] , and [Formula: see text] , respectively) in patients receiving SRT than in conventional radiotherapy portals ([Formula: see text] , [Formula: see text] , and [Formula: see text]). But the average doses to the right eye ([Formula: see text]) and to the left eye ([Formula: see text]) in the stereotactic group were less when compared with the patients treated with conventional radiotherapy, who received [Formula: see text] and [Formula: see text] , respectively. In conclusion, SRT is definitely superior to conventional radiotherapy as far as dose to the surrounding normal structures is concerned. The higher extracranial doses in SRT seem to be within the acceptable range; however, the clinical significance of this is still unclear and needs longer followup. PACS number: 87.53.Ly