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Extracranial doses in stereotactic and conventional radiotherapy for pituitary adenomas
The purpose of this study is to determine the extracranial dose in patients treated for pituitary adenoma with conventional and stereotactic radiotherapy (SRT). Twelve patients receiving treatment with radiation for pituitary adenoma were selected. Six patients underwent SRT, and six patients underw...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2006
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5722438/ https://www.ncbi.nlm.nih.gov/pubmed/17533326 http://dx.doi.org/10.1120/jacmp.v7i2.2203 |
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author | Ram, Thomas Samuel Ravindran, Paul B. Viswanathan, Faith R. Viswanathan, Perungulam Narayan Pavamani, Simon P. |
author_facet | Ram, Thomas Samuel Ravindran, Paul B. Viswanathan, Faith R. Viswanathan, Perungulam Narayan Pavamani, Simon P. |
author_sort | Ram, Thomas Samuel |
collection | PubMed |
description | The purpose of this study is to determine the extracranial dose in patients treated for pituitary adenoma with conventional and stereotactic radiotherapy (SRT). Twelve patients receiving treatment with radiation for pituitary adenoma were selected. Six patients underwent SRT, and six patients underwent conventional radiotherapy. Extracranial doses were measured with pre‐irradiation annealed lithium fluoride thermoluminscent dosimetry (TLD) chips. The chips were wrapped and placed on the patients’ skin, over each eyelid, the thyroid, chest, and scrotum for males and over the suprapubic region for females. Postradiation annealing was done, and the TLDs were read in a TLD reader system. The results were analyzed using the Wilcoxon matched‐pairs signed rank test by SPSS, version 6.01. The doses to the thyroid, center, and gonads were significantly higher ([Formula: see text] , [Formula: see text] , and [Formula: see text] , respectively) in patients receiving SRT than in conventional radiotherapy portals ([Formula: see text] , [Formula: see text] , and [Formula: see text]). But the average doses to the right eye ([Formula: see text]) and to the left eye ([Formula: see text]) in the stereotactic group were less when compared with the patients treated with conventional radiotherapy, who received [Formula: see text] and [Formula: see text] , respectively. In conclusion, SRT is definitely superior to conventional radiotherapy as far as dose to the surrounding normal structures is concerned. The higher extracranial doses in SRT seem to be within the acceptable range; however, the clinical significance of this is still unclear and needs longer followup. PACS number: 87.53.Ly |
format | Online Article Text |
id | pubmed-5722438 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2006 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-57224382018-04-02 Extracranial doses in stereotactic and conventional radiotherapy for pituitary adenomas Ram, Thomas Samuel Ravindran, Paul B. Viswanathan, Faith R. Viswanathan, Perungulam Narayan Pavamani, Simon P. J Appl Clin Med Phys Radiation Measurements The purpose of this study is to determine the extracranial dose in patients treated for pituitary adenoma with conventional and stereotactic radiotherapy (SRT). Twelve patients receiving treatment with radiation for pituitary adenoma were selected. Six patients underwent SRT, and six patients underwent conventional radiotherapy. Extracranial doses were measured with pre‐irradiation annealed lithium fluoride thermoluminscent dosimetry (TLD) chips. The chips were wrapped and placed on the patients’ skin, over each eyelid, the thyroid, chest, and scrotum for males and over the suprapubic region for females. Postradiation annealing was done, and the TLDs were read in a TLD reader system. The results were analyzed using the Wilcoxon matched‐pairs signed rank test by SPSS, version 6.01. The doses to the thyroid, center, and gonads were significantly higher ([Formula: see text] , [Formula: see text] , and [Formula: see text] , respectively) in patients receiving SRT than in conventional radiotherapy portals ([Formula: see text] , [Formula: see text] , and [Formula: see text]). But the average doses to the right eye ([Formula: see text]) and to the left eye ([Formula: see text]) in the stereotactic group were less when compared with the patients treated with conventional radiotherapy, who received [Formula: see text] and [Formula: see text] , respectively. In conclusion, SRT is definitely superior to conventional radiotherapy as far as dose to the surrounding normal structures is concerned. The higher extracranial doses in SRT seem to be within the acceptable range; however, the clinical significance of this is still unclear and needs longer followup. PACS number: 87.53.Ly John Wiley and Sons Inc. 2006-05-25 /pmc/articles/PMC5722438/ /pubmed/17533326 http://dx.doi.org/10.1120/jacmp.v7i2.2203 Text en © 2006 The Authors. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/3.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Radiation Measurements Ram, Thomas Samuel Ravindran, Paul B. Viswanathan, Faith R. Viswanathan, Perungulam Narayan Pavamani, Simon P. Extracranial doses in stereotactic and conventional radiotherapy for pituitary adenomas |
title | Extracranial doses in stereotactic and conventional radiotherapy for pituitary adenomas |
title_full | Extracranial doses in stereotactic and conventional radiotherapy for pituitary adenomas |
title_fullStr | Extracranial doses in stereotactic and conventional radiotherapy for pituitary adenomas |
title_full_unstemmed | Extracranial doses in stereotactic and conventional radiotherapy for pituitary adenomas |
title_short | Extracranial doses in stereotactic and conventional radiotherapy for pituitary adenomas |
title_sort | extracranial doses in stereotactic and conventional radiotherapy for pituitary adenomas |
topic | Radiation Measurements |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5722438/ https://www.ncbi.nlm.nih.gov/pubmed/17533326 http://dx.doi.org/10.1120/jacmp.v7i2.2203 |
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