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Peripheral blood microRNAs expression is associated with infant respiratory syncytial virus infection
MicroRNAs respond to the inflammatory responses induced by RNA virus infection. In this study, we investigated the specific microRNA profile in the peripheral blood of infants infected with respiratory syncytial virus (RSV). Blood specimens were analyzed using microRNA microarrays, followed by quant...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5722509/ https://www.ncbi.nlm.nih.gov/pubmed/29228557 http://dx.doi.org/10.18632/oncotarget.19364 |
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author | Wang, Shouyi Liu, Pin Yang, Pu Zheng, Junwen Zhao, Dongchi |
author_facet | Wang, Shouyi Liu, Pin Yang, Pu Zheng, Junwen Zhao, Dongchi |
author_sort | Wang, Shouyi |
collection | PubMed |
description | MicroRNAs respond to the inflammatory responses induced by RNA virus infection. In this study, we investigated the specific microRNA profile in the peripheral blood of infants infected with respiratory syncytial virus (RSV). Blood specimens were analyzed using microRNA microarrays, followed by quantitative RT-PCR. A specific microRNA profile in the peripheral blood of RSV-infected infants was identified for the first time. MiR-106b-5p, miR-20b-5p, and miR-342-3p were upregulated, while miR-320e, miR-320d, miR-877-5p, miR-122-5p, and miR-92b-5p were downregulated. Pathway analysis indicated that the dysregulated microRNAs were involved in inflammatory and immune responses, including Wnt, TGF-β, insulin, and T and B cell receptor signaling. These results demonstrate that RSV infection associates with a distinct microRNA fingerprint and suggest that RSV induces inflammatory responses in infants. |
format | Online Article Text |
id | pubmed-5722509 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-57225092017-12-10 Peripheral blood microRNAs expression is associated with infant respiratory syncytial virus infection Wang, Shouyi Liu, Pin Yang, Pu Zheng, Junwen Zhao, Dongchi Oncotarget Research Paper: Immunology MicroRNAs respond to the inflammatory responses induced by RNA virus infection. In this study, we investigated the specific microRNA profile in the peripheral blood of infants infected with respiratory syncytial virus (RSV). Blood specimens were analyzed using microRNA microarrays, followed by quantitative RT-PCR. A specific microRNA profile in the peripheral blood of RSV-infected infants was identified for the first time. MiR-106b-5p, miR-20b-5p, and miR-342-3p were upregulated, while miR-320e, miR-320d, miR-877-5p, miR-122-5p, and miR-92b-5p were downregulated. Pathway analysis indicated that the dysregulated microRNAs were involved in inflammatory and immune responses, including Wnt, TGF-β, insulin, and T and B cell receptor signaling. These results demonstrate that RSV infection associates with a distinct microRNA fingerprint and suggest that RSV induces inflammatory responses in infants. Impact Journals LLC 2017-07-18 /pmc/articles/PMC5722509/ /pubmed/29228557 http://dx.doi.org/10.18632/oncotarget.19364 Text en Copyright: © 2017 Wang et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper: Immunology Wang, Shouyi Liu, Pin Yang, Pu Zheng, Junwen Zhao, Dongchi Peripheral blood microRNAs expression is associated with infant respiratory syncytial virus infection |
title | Peripheral blood microRNAs expression is associated with infant respiratory syncytial virus infection |
title_full | Peripheral blood microRNAs expression is associated with infant respiratory syncytial virus infection |
title_fullStr | Peripheral blood microRNAs expression is associated with infant respiratory syncytial virus infection |
title_full_unstemmed | Peripheral blood microRNAs expression is associated with infant respiratory syncytial virus infection |
title_short | Peripheral blood microRNAs expression is associated with infant respiratory syncytial virus infection |
title_sort | peripheral blood micrornas expression is associated with infant respiratory syncytial virus infection |
topic | Research Paper: Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5722509/ https://www.ncbi.nlm.nih.gov/pubmed/29228557 http://dx.doi.org/10.18632/oncotarget.19364 |
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