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A genetic variant in SLC28A3, rs56350726, is associated with progression to castration-resistant prostate cancer in a Korean population with metastatic prostate cancer

BACKGROUND: Genetic variation which related with progression to castration-resistant prostate cancer (CRPC) during androgen-deprivation therapy (ADT) has not been elucidated in patients with metastatic prostate cancer (mPCa). Therefore, we assessed the association between genetic variats in mPCa and...

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Autores principales: Jo, Jung Ku, Oh, Jong Jin, Kim, Yong Tae, Moon, Hong Sang, Choi, Hong Yong, Park, Seunghyun, Ho, Jin-Nyoung, Yoon, Sungroh, Park, Hae Young, Byun, Seok-Soo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5722531/
https://www.ncbi.nlm.nih.gov/pubmed/29228579
http://dx.doi.org/10.18632/oncotarget.18298
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author Jo, Jung Ku
Oh, Jong Jin
Kim, Yong Tae
Moon, Hong Sang
Choi, Hong Yong
Park, Seunghyun
Ho, Jin-Nyoung
Yoon, Sungroh
Park, Hae Young
Byun, Seok-Soo
author_facet Jo, Jung Ku
Oh, Jong Jin
Kim, Yong Tae
Moon, Hong Sang
Choi, Hong Yong
Park, Seunghyun
Ho, Jin-Nyoung
Yoon, Sungroh
Park, Hae Young
Byun, Seok-Soo
author_sort Jo, Jung Ku
collection PubMed
description BACKGROUND: Genetic variation which related with progression to castration-resistant prostate cancer (CRPC) during androgen-deprivation therapy (ADT) has not been elucidated in patients with metastatic prostate cancer (mPCa). Therefore, we assessed the association between genetic variats in mPCa and progession to CRPC. RESULTS: Analysis of exome genotypes revealed that 42 SNPs were significantly associated with mPCa. The top five polymorphisms were statistically significantly associated with metastatic disease. In addition, one of these SNPs, rs56350726, was significantly associated with time to CRPC in Kaplan-Meier analysis (Log-rank test, p = 0.011). In multivariable Cox regression, rs56350726 was strongly associated with progression to CRPC (HR = 4.172 95% CI = 1.223-14.239, p = 0.023). MATERIALS AND METHODS: We assessed genetic variation among 1000 patients with PCa with or without metastasis, using 242,221 single nucleotide polymorphisms (SNPs) on the custom HumanExome BeadChip v1.0 (Illuminam Inc.). We analyzed the time to CRPC in 110 of the 1000 patients who were treated with ADT. Genetic data were analyzed using unconditional logistic regression and odds ratios calculated as estimates of relative risk of metastasis. We identified SNPs associated with metastasis and analyzed the relationship between these SNPs and time to CRPC in mPCa. CONCLUSIONS: Based on a genetic variation, the five top SNPs were observed to associate with mPCa. And one (SLC28A3, rs56350726) of five SNP was found the association with the progression to CRPC in patients with mPCa.
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spelling pubmed-57225312017-12-10 A genetic variant in SLC28A3, rs56350726, is associated with progression to castration-resistant prostate cancer in a Korean population with metastatic prostate cancer Jo, Jung Ku Oh, Jong Jin Kim, Yong Tae Moon, Hong Sang Choi, Hong Yong Park, Seunghyun Ho, Jin-Nyoung Yoon, Sungroh Park, Hae Young Byun, Seok-Soo Oncotarget Research Paper BACKGROUND: Genetic variation which related with progression to castration-resistant prostate cancer (CRPC) during androgen-deprivation therapy (ADT) has not been elucidated in patients with metastatic prostate cancer (mPCa). Therefore, we assessed the association between genetic variats in mPCa and progession to CRPC. RESULTS: Analysis of exome genotypes revealed that 42 SNPs were significantly associated with mPCa. The top five polymorphisms were statistically significantly associated with metastatic disease. In addition, one of these SNPs, rs56350726, was significantly associated with time to CRPC in Kaplan-Meier analysis (Log-rank test, p = 0.011). In multivariable Cox regression, rs56350726 was strongly associated with progression to CRPC (HR = 4.172 95% CI = 1.223-14.239, p = 0.023). MATERIALS AND METHODS: We assessed genetic variation among 1000 patients with PCa with or without metastasis, using 242,221 single nucleotide polymorphisms (SNPs) on the custom HumanExome BeadChip v1.0 (Illuminam Inc.). We analyzed the time to CRPC in 110 of the 1000 patients who were treated with ADT. Genetic data were analyzed using unconditional logistic regression and odds ratios calculated as estimates of relative risk of metastasis. We identified SNPs associated with metastasis and analyzed the relationship between these SNPs and time to CRPC in mPCa. CONCLUSIONS: Based on a genetic variation, the five top SNPs were observed to associate with mPCa. And one (SLC28A3, rs56350726) of five SNP was found the association with the progression to CRPC in patients with mPCa. Impact Journals LLC 2017-05-30 /pmc/articles/PMC5722531/ /pubmed/29228579 http://dx.doi.org/10.18632/oncotarget.18298 Text en Copyright: © 2017 Jo et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Jo, Jung Ku
Oh, Jong Jin
Kim, Yong Tae
Moon, Hong Sang
Choi, Hong Yong
Park, Seunghyun
Ho, Jin-Nyoung
Yoon, Sungroh
Park, Hae Young
Byun, Seok-Soo
A genetic variant in SLC28A3, rs56350726, is associated with progression to castration-resistant prostate cancer in a Korean population with metastatic prostate cancer
title A genetic variant in SLC28A3, rs56350726, is associated with progression to castration-resistant prostate cancer in a Korean population with metastatic prostate cancer
title_full A genetic variant in SLC28A3, rs56350726, is associated with progression to castration-resistant prostate cancer in a Korean population with metastatic prostate cancer
title_fullStr A genetic variant in SLC28A3, rs56350726, is associated with progression to castration-resistant prostate cancer in a Korean population with metastatic prostate cancer
title_full_unstemmed A genetic variant in SLC28A3, rs56350726, is associated with progression to castration-resistant prostate cancer in a Korean population with metastatic prostate cancer
title_short A genetic variant in SLC28A3, rs56350726, is associated with progression to castration-resistant prostate cancer in a Korean population with metastatic prostate cancer
title_sort genetic variant in slc28a3, rs56350726, is associated with progression to castration-resistant prostate cancer in a korean population with metastatic prostate cancer
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5722531/
https://www.ncbi.nlm.nih.gov/pubmed/29228579
http://dx.doi.org/10.18632/oncotarget.18298
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