A genome-wide screen for FTY720-sensitive mutants reveals genes required for ROS homeostasis

Fingolimod hydrochloride (FTY720), a sphingosine-1-phosphate (S1P) analogue, is an approved immune modulator for the treatment of multiple sclerosis (MS). Notably, in addition to its well-known mode of action as an S1P modulator, accumulating evidence suggests that FTY720 induces apoptosis in variou...

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Detalles Bibliográficos
Autores principales: Hagihara, Kanako, Kinoshita, Kanako, Ishida, Kouki, Hojo, Shihomi, Kameoka, Yoshinori, Satoh, Ryosuke, Takasaki, Teruaki, Sugiura, Reiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shared Science Publishers OG 2017
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5722642/
https://www.ncbi.nlm.nih.gov/pubmed/29234668
http://dx.doi.org/10.15698/mic2017.12.601

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