Mitochondrial energy metabolism is required for lifespan extension by the spastic paraplegia-associated protein spartin

Hereditary spastic paraplegias, a group of neurodegenerative disorders, can be caused by loss-of-function mutations in the protein spartin. However, the physiological role of spartin remains largely elusive. Here we show that heterologous expression of human or Drosophila spartin extends chronologic...

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Detalles Bibliográficos
Autores principales: Ring, Julia, Rockenfeller, Patrick, Abraham, Claudia, Tadic, Jelena, Poglitsch, Michael, Schimmel, Katherina, Westermayer, Julia, Schauer, Simon, Achleitner, Bettina, Schimpel, Christa, Moitzi, Barbara, Rechberger, Gerald N., Sigrist, Stephan J., Carmona-Gutierrez, Didac, Kroemer, Guido, Büttner, Sabrina, Eisenberg, Tobias, Madeo, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shared Science Publishers OG 2017
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5722644/
https://www.ncbi.nlm.nih.gov/pubmed/29234670
http://dx.doi.org/10.15698/mic2017.12.603

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