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Tip-enhanced ablation and ionization mass spectrometry for nanoscale chemical analysis
Spectroscopic methods with nanoscale lateral resolution are becoming essential in the fields of physics, chemistry, geology, biology, and materials science. However, the lateral resolution of laser-based mass spectrometry imaging (MSI) techniques has so far been limited to the microscale. This repor...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for the Advancement of Science
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5722649/ https://www.ncbi.nlm.nih.gov/pubmed/29226250 http://dx.doi.org/10.1126/sciadv.aaq1059 |
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author | Liang, Zhisen Zhang, Shudi Li, Xiaoping Wang, Tongtong Huang, Yaping Hang, Wei Yang, Zhilin Li, Jianfeng Tian, Zhongqun |
author_facet | Liang, Zhisen Zhang, Shudi Li, Xiaoping Wang, Tongtong Huang, Yaping Hang, Wei Yang, Zhilin Li, Jianfeng Tian, Zhongqun |
author_sort | Liang, Zhisen |
collection | PubMed |
description | Spectroscopic methods with nanoscale lateral resolution are becoming essential in the fields of physics, chemistry, geology, biology, and materials science. However, the lateral resolution of laser-based mass spectrometry imaging (MSI) techniques has so far been limited to the microscale. This report presents the development of tip-enhanced ablation and ionization time-of-flight mass spectrometry (TEAI-TOFMS), using a shell-isolated apertureless silver tip. The TEAI-TOFMS results indicate the capability and reproducibility of the system for generating nanosized craters and for acquiring the corresponding mass spectral signals. Multi-elemental analysis of nine inorganic salt residues and MSI of a potassium salt residue pattern at a 50-nm lateral resolution were achieved. These results demonstrate the opportunity for the distribution of chemical compositions at the nanoscale to be visualized. |
format | Online Article Text |
id | pubmed-5722649 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | American Association for the Advancement of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-57226492017-12-10 Tip-enhanced ablation and ionization mass spectrometry for nanoscale chemical analysis Liang, Zhisen Zhang, Shudi Li, Xiaoping Wang, Tongtong Huang, Yaping Hang, Wei Yang, Zhilin Li, Jianfeng Tian, Zhongqun Sci Adv Research Articles Spectroscopic methods with nanoscale lateral resolution are becoming essential in the fields of physics, chemistry, geology, biology, and materials science. However, the lateral resolution of laser-based mass spectrometry imaging (MSI) techniques has so far been limited to the microscale. This report presents the development of tip-enhanced ablation and ionization time-of-flight mass spectrometry (TEAI-TOFMS), using a shell-isolated apertureless silver tip. The TEAI-TOFMS results indicate the capability and reproducibility of the system for generating nanosized craters and for acquiring the corresponding mass spectral signals. Multi-elemental analysis of nine inorganic salt residues and MSI of a potassium salt residue pattern at a 50-nm lateral resolution were achieved. These results demonstrate the opportunity for the distribution of chemical compositions at the nanoscale to be visualized. American Association for the Advancement of Science 2017-12-08 /pmc/articles/PMC5722649/ /pubmed/29226250 http://dx.doi.org/10.1126/sciadv.aaq1059 Text en Copyright © 2017 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). http://creativecommons.org/licenses/by-nc/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license (http://creativecommons.org/licenses/by-nc/4.0/) , which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited. |
spellingShingle | Research Articles Liang, Zhisen Zhang, Shudi Li, Xiaoping Wang, Tongtong Huang, Yaping Hang, Wei Yang, Zhilin Li, Jianfeng Tian, Zhongqun Tip-enhanced ablation and ionization mass spectrometry for nanoscale chemical analysis |
title | Tip-enhanced ablation and ionization mass spectrometry for nanoscale chemical analysis |
title_full | Tip-enhanced ablation and ionization mass spectrometry for nanoscale chemical analysis |
title_fullStr | Tip-enhanced ablation and ionization mass spectrometry for nanoscale chemical analysis |
title_full_unstemmed | Tip-enhanced ablation and ionization mass spectrometry for nanoscale chemical analysis |
title_short | Tip-enhanced ablation and ionization mass spectrometry for nanoscale chemical analysis |
title_sort | tip-enhanced ablation and ionization mass spectrometry for nanoscale chemical analysis |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5722649/ https://www.ncbi.nlm.nih.gov/pubmed/29226250 http://dx.doi.org/10.1126/sciadv.aaq1059 |
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