A Combined In Vivo HSC Transduction/Selection Approach Results in Efficient and Stable Gene Expression in Peripheral Blood Cells in Mice

We recently reported on an in vivo hematopoietic stem cell (HSC) gene therapy approach. It involves the subcutaneous injections of G-CSF/AMD3100 to mobilize HSCs from the bone marrow into the peripheral blood stream and the intravenous injection of an integrating helper-dependent adenovirus vector s...

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Detalles Bibliográficos
Autores principales: Wang, Hongjie, Richter, Maximilian, Psatha, Nikoletta, Li, Chang, Kim, Jiho, Liu, Jing, Ehrhardt, Anja, Nilsson, Susan K., Cao, Benjamin, Palmer, Donna, Ng, Philip, Izsvák, Zsuzsanna, Haworth, Kevin G., Kiem, Hans-Peter, Papayannopoulou, Thalia, Lieber, André
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5722719/
https://www.ncbi.nlm.nih.gov/pubmed/29255741
http://dx.doi.org/10.1016/j.omtm.2017.11.004

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