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Neoadjuvant Chemoradiotherapy for Stage III Non-Small Cell Lung Cancer
The local management of stage III non-small cell lung cancer is controversial. Although definitive chemoradiotherapy (CRT) is considered a standard-of-care in the curative management of the disease, inadequate local control outcomes have led to various treatment strategies that incorporate surgical...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2017
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5722802/ https://www.ncbi.nlm.nih.gov/pubmed/29255697 http://dx.doi.org/10.3389/fonc.2017.00281 |
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author | Sher, David J. |
author_facet | Sher, David J. |
author_sort | Sher, David J. |
collection | PubMed |
description | The local management of stage III non-small cell lung cancer is controversial. Although definitive chemoradiotherapy (CRT) is considered a standard-of-care in the curative management of the disease, inadequate local control outcomes have led to various treatment strategies that incorporate surgical resection. Surgery alone has long been recognized as insufficient for this stage, and thus neoadjuvant strategies have been developed to treat micrometastatic disease and increase the probability of a complete resection. The optimal induction strategy has not yet been defined, however, with arguments favoring either preoperative chemotherapy or CRT. In this article, the data supporting the use of neoadjuvant CRT and the randomized literature comparing the two approaches will be reviewed. The article will conclude with summary comparisons of these induction paradigms. |
format | Online Article Text |
id | pubmed-5722802 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-57228022017-12-18 Neoadjuvant Chemoradiotherapy for Stage III Non-Small Cell Lung Cancer Sher, David J. Front Oncol Oncology The local management of stage III non-small cell lung cancer is controversial. Although definitive chemoradiotherapy (CRT) is considered a standard-of-care in the curative management of the disease, inadequate local control outcomes have led to various treatment strategies that incorporate surgical resection. Surgery alone has long been recognized as insufficient for this stage, and thus neoadjuvant strategies have been developed to treat micrometastatic disease and increase the probability of a complete resection. The optimal induction strategy has not yet been defined, however, with arguments favoring either preoperative chemotherapy or CRT. In this article, the data supporting the use of neoadjuvant CRT and the randomized literature comparing the two approaches will be reviewed. The article will conclude with summary comparisons of these induction paradigms. Frontiers Media S.A. 2017-12-04 /pmc/articles/PMC5722802/ /pubmed/29255697 http://dx.doi.org/10.3389/fonc.2017.00281 Text en Copyright © 2017 Sher. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Sher, David J. Neoadjuvant Chemoradiotherapy for Stage III Non-Small Cell Lung Cancer |
title | Neoadjuvant Chemoradiotherapy for Stage III Non-Small Cell Lung Cancer |
title_full | Neoadjuvant Chemoradiotherapy for Stage III Non-Small Cell Lung Cancer |
title_fullStr | Neoadjuvant Chemoradiotherapy for Stage III Non-Small Cell Lung Cancer |
title_full_unstemmed | Neoadjuvant Chemoradiotherapy for Stage III Non-Small Cell Lung Cancer |
title_short | Neoadjuvant Chemoradiotherapy for Stage III Non-Small Cell Lung Cancer |
title_sort | neoadjuvant chemoradiotherapy for stage iii non-small cell lung cancer |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5722802/ https://www.ncbi.nlm.nih.gov/pubmed/29255697 http://dx.doi.org/10.3389/fonc.2017.00281 |
work_keys_str_mv | AT sherdavidj neoadjuvantchemoradiotherapyforstageiiinonsmallcelllungcancer |