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Phenylephrine Affects Peripapillary Retinal Vasculature—an Optic Coherence Tomography Angiography Study

Purpose: To evaluate and compare the effect of topical mydriatic eye drops (0.5% tropicamide alone, and a 0.5% tropicamide/0.5% phenylephrine mixture) on the retinal perfusion using optic coherence tomography angiography (OCTA). Methods: The perfused vessel density in the macular and peripapillary a...

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Autores principales: Cheng, Jingyi, Yu, Jian, Jiang, Chunhui, Sun, Xinghuai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5722831/
https://www.ncbi.nlm.nih.gov/pubmed/29255424
http://dx.doi.org/10.3389/fphys.2017.00996
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author Cheng, Jingyi
Yu, Jian
Jiang, Chunhui
Sun, Xinghuai
author_facet Cheng, Jingyi
Yu, Jian
Jiang, Chunhui
Sun, Xinghuai
author_sort Cheng, Jingyi
collection PubMed
description Purpose: To evaluate and compare the effect of topical mydriatic eye drops (0.5% tropicamide alone, and a 0.5% tropicamide/0.5% phenylephrine mixture) on the retinal perfusion using optic coherence tomography angiography (OCTA). Methods: The perfused vessel density in the macular and peripapillary areas of both eyes was measured in eight healthy subjects using OCTA and a split-spectrum amplitude decorrelation angiography algorithm (SSADA). Various parameters, including retinal vessel density, were obtained at baseline and again 30 min after the instillation of either the tropicamide or the tropicamide/phenylephrine mixture eye drops in the right eye. Results: Following instillation of the tropicamide/phenylephrine mixture eye drops, there was a significant reduction of vessel density in the peripapillary area (from 89.63 ± 4.53% to 85.00 ± 4.14%, P = 0.034), but not in the macular areas. The mean effect size in the peripapillary area was −4.63%, and was not correlated with age, sex, or baseline vessel density. There was no reduction in vessel density in the macular or peripapillary areas after instillation of 0.5% tropicamide alone, and no reduction in vessel density in the contralateral (control) eyes. Conclusion: Topical phenylephrine reduced the retinal vessel density within the peripapillary area, but not within the macular area. Therefore, studies using OCTA, especially those focusing on the peripapillary area, should take into account this effect of phenylephrine on vessel density.
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spelling pubmed-57228312017-12-18 Phenylephrine Affects Peripapillary Retinal Vasculature—an Optic Coherence Tomography Angiography Study Cheng, Jingyi Yu, Jian Jiang, Chunhui Sun, Xinghuai Front Physiol Physiology Purpose: To evaluate and compare the effect of topical mydriatic eye drops (0.5% tropicamide alone, and a 0.5% tropicamide/0.5% phenylephrine mixture) on the retinal perfusion using optic coherence tomography angiography (OCTA). Methods: The perfused vessel density in the macular and peripapillary areas of both eyes was measured in eight healthy subjects using OCTA and a split-spectrum amplitude decorrelation angiography algorithm (SSADA). Various parameters, including retinal vessel density, were obtained at baseline and again 30 min after the instillation of either the tropicamide or the tropicamide/phenylephrine mixture eye drops in the right eye. Results: Following instillation of the tropicamide/phenylephrine mixture eye drops, there was a significant reduction of vessel density in the peripapillary area (from 89.63 ± 4.53% to 85.00 ± 4.14%, P = 0.034), but not in the macular areas. The mean effect size in the peripapillary area was −4.63%, and was not correlated with age, sex, or baseline vessel density. There was no reduction in vessel density in the macular or peripapillary areas after instillation of 0.5% tropicamide alone, and no reduction in vessel density in the contralateral (control) eyes. Conclusion: Topical phenylephrine reduced the retinal vessel density within the peripapillary area, but not within the macular area. Therefore, studies using OCTA, especially those focusing on the peripapillary area, should take into account this effect of phenylephrine on vessel density. Frontiers Media S.A. 2017-12-04 /pmc/articles/PMC5722831/ /pubmed/29255424 http://dx.doi.org/10.3389/fphys.2017.00996 Text en Copyright © 2017 Cheng, Yu, Jiang and Sun. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Cheng, Jingyi
Yu, Jian
Jiang, Chunhui
Sun, Xinghuai
Phenylephrine Affects Peripapillary Retinal Vasculature—an Optic Coherence Tomography Angiography Study
title Phenylephrine Affects Peripapillary Retinal Vasculature—an Optic Coherence Tomography Angiography Study
title_full Phenylephrine Affects Peripapillary Retinal Vasculature—an Optic Coherence Tomography Angiography Study
title_fullStr Phenylephrine Affects Peripapillary Retinal Vasculature—an Optic Coherence Tomography Angiography Study
title_full_unstemmed Phenylephrine Affects Peripapillary Retinal Vasculature—an Optic Coherence Tomography Angiography Study
title_short Phenylephrine Affects Peripapillary Retinal Vasculature—an Optic Coherence Tomography Angiography Study
title_sort phenylephrine affects peripapillary retinal vasculature—an optic coherence tomography angiography study
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5722831/
https://www.ncbi.nlm.nih.gov/pubmed/29255424
http://dx.doi.org/10.3389/fphys.2017.00996
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