Computational insights for the hydride transfer and distinctive roles of key residues in cholesterol oxidase

Cholesterol oxidase (ChOx), a member of the glucose-methanol-choline (GMC) family, catalyzes the oxidation of the substrate via a hydride transfer mechanism and concomitant reduction of the FAD cofactor. Unlike other GMC enzymes, the conserved His447 is not the catalytic base that deprotonates the s...

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Detalles Bibliográficos
Autores principales: Yu, Li-Juan, Golden, Emily, Chen, Nanhao, Zhao, Yuan, Vrielink, Alice, Karton, Amir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5722936/
https://www.ncbi.nlm.nih.gov/pubmed/29222497
http://dx.doi.org/10.1038/s41598-017-17503-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5722936/
https://www.ncbi.nlm.nih.gov/pubmed/29222497
http://dx.doi.org/10.1038/s41598-017-17503-x

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