Cargando…

Computational insights for the hydride transfer and distinctive roles of key residues in cholesterol oxidase

Cholesterol oxidase (ChOx), a member of the glucose-methanol-choline (GMC) family, catalyzes the oxidation of the substrate via a hydride transfer mechanism and concomitant reduction of the FAD cofactor. Unlike other GMC enzymes, the conserved His447 is not the catalytic base that deprotonates the s...

Descripción completa

Detalles Bibliográficos
Autores principales: Yu, Li-Juan, Golden, Emily, Chen, Nanhao, Zhao, Yuan, Vrielink, Alice, Karton, Amir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5722936/
https://www.ncbi.nlm.nih.gov/pubmed/29222497
http://dx.doi.org/10.1038/s41598-017-17503-x