The Role of Estrogen Membrane Receptor (G Protein-Coupled Estrogen Receptor 1) in Skin Inflammation Induced by Systemic Lupus Erythematosus Serum IgG

Skin injury is the second most common clinical manifestation in patients with systemic lupus erythematosus (SLE). Estrogen may affect the onset and development of SLE through its receptor. In this study, we investigated the role of estrogen membrane receptor G protein-coupled estrogen receptor 1 (GP...

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Autores principales: Cai, Zhenming, Xie, Changhao, Qiao, Wei, Fei, Xibin, Guo, Xuanxuan, Liu, Huicheng, Li, Xiaoyan, Fang, Xiang, Xu, Guangqiong, Dou, Hui, Deng, Guo-Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5722986/
https://www.ncbi.nlm.nih.gov/pubmed/29255468
http://dx.doi.org/10.3389/fimmu.2017.01723
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author Cai, Zhenming
Xie, Changhao
Qiao, Wei
Fei, Xibin
Guo, Xuanxuan
Liu, Huicheng
Li, Xiaoyan
Fang, Xiang
Xu, Guangqiong
Dou, Hui
Deng, Guo-Min
author_facet Cai, Zhenming
Xie, Changhao
Qiao, Wei
Fei, Xibin
Guo, Xuanxuan
Liu, Huicheng
Li, Xiaoyan
Fang, Xiang
Xu, Guangqiong
Dou, Hui
Deng, Guo-Min
author_sort Cai, Zhenming
collection PubMed
description Skin injury is the second most common clinical manifestation in patients with systemic lupus erythematosus (SLE). Estrogen may affect the onset and development of SLE through its receptor. In this study, we investigated the role of estrogen membrane receptor G protein-coupled estrogen receptor 1 (GPER1) in skin injury of SLE. We found that skin injury induced by SLE serum was more severe in female mice and required monocytes. Estrogen promoted activation of monocytes induced by lupus IgG through the membrane receptor GPER1 which was located in lipid rafts. Blockade of GPER1 and lipid rafts reduced skin inflammation induced by SLE serum. The results we obtained suggest that GPER1 plays an important role in the pathogenesis of skin inflammation induced by lupus IgG and might be a therapeutic target in skin lesions of patients with SLE.
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spelling pubmed-57229862017-12-18 The Role of Estrogen Membrane Receptor (G Protein-Coupled Estrogen Receptor 1) in Skin Inflammation Induced by Systemic Lupus Erythematosus Serum IgG Cai, Zhenming Xie, Changhao Qiao, Wei Fei, Xibin Guo, Xuanxuan Liu, Huicheng Li, Xiaoyan Fang, Xiang Xu, Guangqiong Dou, Hui Deng, Guo-Min Front Immunol Immunology Skin injury is the second most common clinical manifestation in patients with systemic lupus erythematosus (SLE). Estrogen may affect the onset and development of SLE through its receptor. In this study, we investigated the role of estrogen membrane receptor G protein-coupled estrogen receptor 1 (GPER1) in skin injury of SLE. We found that skin injury induced by SLE serum was more severe in female mice and required monocytes. Estrogen promoted activation of monocytes induced by lupus IgG through the membrane receptor GPER1 which was located in lipid rafts. Blockade of GPER1 and lipid rafts reduced skin inflammation induced by SLE serum. The results we obtained suggest that GPER1 plays an important role in the pathogenesis of skin inflammation induced by lupus IgG and might be a therapeutic target in skin lesions of patients with SLE. Frontiers Media S.A. 2017-12-04 /pmc/articles/PMC5722986/ /pubmed/29255468 http://dx.doi.org/10.3389/fimmu.2017.01723 Text en Copyright © 2017 Cai, Xie, Qiao, Fei, Guo, Liu, Li, Fang, Xu, Dou and Deng. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Cai, Zhenming
Xie, Changhao
Qiao, Wei
Fei, Xibin
Guo, Xuanxuan
Liu, Huicheng
Li, Xiaoyan
Fang, Xiang
Xu, Guangqiong
Dou, Hui
Deng, Guo-Min
The Role of Estrogen Membrane Receptor (G Protein-Coupled Estrogen Receptor 1) in Skin Inflammation Induced by Systemic Lupus Erythematosus Serum IgG
title The Role of Estrogen Membrane Receptor (G Protein-Coupled Estrogen Receptor 1) in Skin Inflammation Induced by Systemic Lupus Erythematosus Serum IgG
title_full The Role of Estrogen Membrane Receptor (G Protein-Coupled Estrogen Receptor 1) in Skin Inflammation Induced by Systemic Lupus Erythematosus Serum IgG
title_fullStr The Role of Estrogen Membrane Receptor (G Protein-Coupled Estrogen Receptor 1) in Skin Inflammation Induced by Systemic Lupus Erythematosus Serum IgG
title_full_unstemmed The Role of Estrogen Membrane Receptor (G Protein-Coupled Estrogen Receptor 1) in Skin Inflammation Induced by Systemic Lupus Erythematosus Serum IgG
title_short The Role of Estrogen Membrane Receptor (G Protein-Coupled Estrogen Receptor 1) in Skin Inflammation Induced by Systemic Lupus Erythematosus Serum IgG
title_sort role of estrogen membrane receptor (g protein-coupled estrogen receptor 1) in skin inflammation induced by systemic lupus erythematosus serum igg
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5722986/
https://www.ncbi.nlm.nih.gov/pubmed/29255468
http://dx.doi.org/10.3389/fimmu.2017.01723
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