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A Cdk1 phosphomimic mutant of MCAK impairs microtubule end recognition

The microtubule depolymerising kinesin-13, MCAK, is phosphorylated at residue T537 by Cdk1. This is the only known phosphorylation site within MCAK’s motor domain. To understand the impact of phosphorylation by Cdk1 on microtubule depolymerisation activity, we have investigated the molecular mechani...

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Detalles Bibliográficos
Autores principales:	Belsham, Hannah R., Friel, Claire T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	PeerJ Inc. 2017
Materias:	Biochemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5723132/ https://www.ncbi.nlm.nih.gov/pubmed/29230353 http://dx.doi.org/10.7717/peerj.4034

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