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Contemporary data on treatment practices for low-density lipoprotein cholesterol in 3867 patients who had suffered an acute coronary syndrome across the world

DYSIS II ACS was a longitudinal, observational study in 3867 patients from 18 countries. They were being hospitalized after suffering an acute coronary syndrome. Evaluations were performed at the time of admission and again 120±15 days following the date of admission (the follow-up time point). 2521...

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Autores principales: Gitt, Anselm K., Lautsch, Dominik, Ferrières, Jean, De Ferrari, Gaetano M., Vyas, Ami, Baxter, Carl A., Bash, Lori D., Ashton, Veronica, Horack, Martin, Almahmeed, Wael, Chiang, Fu-Tien, Poh, Kian Keong, Brudi, Philippe, Ambegaonkar, Baishali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5723270/
https://www.ncbi.nlm.nih.gov/pubmed/29234694
http://dx.doi.org/10.1016/j.dib.2017.11.034
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author Gitt, Anselm K.
Lautsch, Dominik
Ferrières, Jean
De Ferrari, Gaetano M.
Vyas, Ami
Baxter, Carl A.
Bash, Lori D.
Ashton, Veronica
Horack, Martin
Almahmeed, Wael
Chiang, Fu-Tien
Poh, Kian Keong
Brudi, Philippe
Ambegaonkar, Baishali
author_facet Gitt, Anselm K.
Lautsch, Dominik
Ferrières, Jean
De Ferrari, Gaetano M.
Vyas, Ami
Baxter, Carl A.
Bash, Lori D.
Ashton, Veronica
Horack, Martin
Almahmeed, Wael
Chiang, Fu-Tien
Poh, Kian Keong
Brudi, Philippe
Ambegaonkar, Baishali
author_sort Gitt, Anselm K.
collection PubMed
description DYSIS II ACS was a longitudinal, observational study in 3867 patients from 18 countries. They were being hospitalized after suffering an acute coronary syndrome. Evaluations were performed at the time of admission and again 120±15 days following the date of admission (the follow-up time point). 2521 patients were on active lipid lowering treatment (LLT) at admission. Mean atorvastatin dose was 22 mg per day and 2.7% received ezetimibe in combination with a statin. At discharge from hospital, 3767 patients received LLT expressed as a mean atorvastatin dose of 36 mg per day with 4.8% receiving ezetimibe on top of a statin. After 120 days, intensity in lipid lowering treatment was reduced to 32 mg per day with 4.9% of the patients receiving ezetimibe and a statin. Of note, during this 4-month follow up period, only 32% of all patients received laboratory lipid testing. 37% attained the low density lipoprotein cholesterol (LDL-C) target value of <70 mg/dl after 120 days. There are differences in the therapy administered as well as in the switch strategies when comparing the data from the respective countries studied. CONCLUSIONS: Only one in three patients achieved the LDL-C target value following only marginal improvements in atorvastatin dose or combination therapy after an ACS event.
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spelling pubmed-57232702017-12-11 Contemporary data on treatment practices for low-density lipoprotein cholesterol in 3867 patients who had suffered an acute coronary syndrome across the world Gitt, Anselm K. Lautsch, Dominik Ferrières, Jean De Ferrari, Gaetano M. Vyas, Ami Baxter, Carl A. Bash, Lori D. Ashton, Veronica Horack, Martin Almahmeed, Wael Chiang, Fu-Tien Poh, Kian Keong Brudi, Philippe Ambegaonkar, Baishali Data Brief Medicine and Dentistry DYSIS II ACS was a longitudinal, observational study in 3867 patients from 18 countries. They were being hospitalized after suffering an acute coronary syndrome. Evaluations were performed at the time of admission and again 120±15 days following the date of admission (the follow-up time point). 2521 patients were on active lipid lowering treatment (LLT) at admission. Mean atorvastatin dose was 22 mg per day and 2.7% received ezetimibe in combination with a statin. At discharge from hospital, 3767 patients received LLT expressed as a mean atorvastatin dose of 36 mg per day with 4.8% receiving ezetimibe on top of a statin. After 120 days, intensity in lipid lowering treatment was reduced to 32 mg per day with 4.9% of the patients receiving ezetimibe and a statin. Of note, during this 4-month follow up period, only 32% of all patients received laboratory lipid testing. 37% attained the low density lipoprotein cholesterol (LDL-C) target value of <70 mg/dl after 120 days. There are differences in the therapy administered as well as in the switch strategies when comparing the data from the respective countries studied. CONCLUSIONS: Only one in three patients achieved the LDL-C target value following only marginal improvements in atorvastatin dose or combination therapy after an ACS event. Elsevier 2017-11-14 /pmc/articles/PMC5723270/ /pubmed/29234694 http://dx.doi.org/10.1016/j.dib.2017.11.034 Text en © 2017 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Medicine and Dentistry
Gitt, Anselm K.
Lautsch, Dominik
Ferrières, Jean
De Ferrari, Gaetano M.
Vyas, Ami
Baxter, Carl A.
Bash, Lori D.
Ashton, Veronica
Horack, Martin
Almahmeed, Wael
Chiang, Fu-Tien
Poh, Kian Keong
Brudi, Philippe
Ambegaonkar, Baishali
Contemporary data on treatment practices for low-density lipoprotein cholesterol in 3867 patients who had suffered an acute coronary syndrome across the world
title Contemporary data on treatment practices for low-density lipoprotein cholesterol in 3867 patients who had suffered an acute coronary syndrome across the world
title_full Contemporary data on treatment practices for low-density lipoprotein cholesterol in 3867 patients who had suffered an acute coronary syndrome across the world
title_fullStr Contemporary data on treatment practices for low-density lipoprotein cholesterol in 3867 patients who had suffered an acute coronary syndrome across the world
title_full_unstemmed Contemporary data on treatment practices for low-density lipoprotein cholesterol in 3867 patients who had suffered an acute coronary syndrome across the world
title_short Contemporary data on treatment practices for low-density lipoprotein cholesterol in 3867 patients who had suffered an acute coronary syndrome across the world
title_sort contemporary data on treatment practices for low-density lipoprotein cholesterol in 3867 patients who had suffered an acute coronary syndrome across the world
topic Medicine and Dentistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5723270/
https://www.ncbi.nlm.nih.gov/pubmed/29234694
http://dx.doi.org/10.1016/j.dib.2017.11.034
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