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High Efficiency Gene Correction in Hematopoietic Cells by Donor-Template-Free CRISPR/Cas9 Genome Editing

The CRISPR/Cas9 prokaryotic adaptive immune system and its swift repurposing for genome editing enables modification of any prespecified genomic sequence with unprecedented accuracy and efficiency, including targeted gene repair. We used the CRISPR/Cas9 system for targeted repair of patient-specific...

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Detalles Bibliográficos
Autores principales:	Sürün, Duran, Schwäble, Joachim, Tomasovic, Ana, Ehling, Roy, Stein, Stefan, Kurrle, Nina, von Melchner, Harald, Schnütgen, Frank
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Gene & Cell Therapy 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5723376/ https://www.ncbi.nlm.nih.gov/pubmed/29499925 http://dx.doi.org/10.1016/j.omtn.2017.11.001

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