Inhibition of Tissue Matrix Metalloproteinases Interferes with Mycobacterium tuberculosis-Induced Granuloma Formation and Reduces Bacterial Load in a Human Lung Tissue Model

Granulomas are hallmarks of pulmonary tuberculosis (TB) and traditionally viewed as host-protective structures. However, recent evidence suggest that Mycobacterium tuberculosis (Mtb) uses its virulence factors to stimulate the formation of granuloma. In the present study, we investigated the contrib...

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Detalles Bibliográficos
Autores principales: Parasa, Venkata R., Muvva, Jagadeeswara R., Rose, Jeronimo F., Braian, Clara, Brighenti, Susanna, Lerm, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5723394/
https://www.ncbi.nlm.nih.gov/pubmed/29259583
http://dx.doi.org/10.3389/fmicb.2017.02370

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5723394/
https://www.ncbi.nlm.nih.gov/pubmed/29259583
http://dx.doi.org/10.3389/fmicb.2017.02370

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