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Inhibition of Tissue Matrix Metalloproteinases Interferes with Mycobacterium tuberculosis-Induced Granuloma Formation and Reduces Bacterial Load in a Human Lung Tissue Model
Granulomas are hallmarks of pulmonary tuberculosis (TB) and traditionally viewed as host-protective structures. However, recent evidence suggest that Mycobacterium tuberculosis (Mtb) uses its virulence factors to stimulate the formation of granuloma. In the present study, we investigated the contrib...
Autores principales: | Parasa, Venkata R., Muvva, Jagadeeswara R., Rose, Jeronimo F., Braian, Clara, Brighenti, Susanna, Lerm, Maria |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5723394/ https://www.ncbi.nlm.nih.gov/pubmed/29259583 http://dx.doi.org/10.3389/fmicb.2017.02370 |
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